Phenolic anti-inflammatory antioxidant reversal of Aβ-induced cognitive deficits and neuropathology
Phenolic anti-inflammatory antioxidant reversal of Aβ-induced cognitive deficits and neuropathology
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DOI：
10.1016/s0197-4580(01)00300-1
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发表时间：
2001-11-01
影响因子：
4.2
通讯作者：
Cole, GM
中科院分区：
文献类型：
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作者：
Frautschy, SA;Hu, W;Cole, GM
氧化损伤和炎症都与年龄相关的神经退行性疾病有关，包括阿尔茨海默病 (AD)。黄咖喱香料姜黄素具有抗氧化和抗炎活性，可显着预防神经毒性和基因毒性物质。我们使用 22 个月的 Sprague-Dawley (SD) 大鼠来比较传统 NSAID、布洛芬和姜黄素预防淀粉样蛋白 β 蛋白 (Aβ) 引起的损伤的效果。脂蛋白载体介导的 Aβ 肽脑室内输注可诱导氧化损伤、突触素损失、小胶质细胞反应和广泛的 Aβ 沉积。膳食姜黄素 (2000 ppm) 可抑制氧化损伤（异前列腺素水平）和突触素损失，但布洛芬则不然。布洛芬和姜黄素都减少了皮质层的小胶质细胞增生，但姜黄素增加了 Aβ-ir 沉积物内部和附近的小胶质细胞标记。在第二组中年雌性 SD 大鼠中，500 ppm 膳食姜黄素可防止 A β 输注引起的莫里斯水迷宫空间记忆缺陷和突触后密度 (PSD)-95 损失，并减少 A β 沉积。由于其低副作用和长期的安全使用历史，姜黄素可能会在 AD 预防方面得到临床应用。 (C) 2001 Elsevier Science Inc. 保留所有权利。
Both oxidative damage and inflammation have been implicated in age-related neurodegenerative diseases including Alzheimer's Disease (AD). The yellow curry spice, curcumin, has both antioxidant and anti-inflammatory activities which confer significant protection against neurotoxic and genotoxic agents. We used 22 month Sprague-Dawley (SD) rats to compare the effects of the conventional NSAID, ibuprofen, and curcumin for their ability to protect against amyloid beta -protein (A beta)-induced damage. Lipoprotein carrier-mediated, intracerebroventricular infusion of A beta peptides induced oxidative damage, synaptophysin loss, a microglial response and widespread A beta deposits. Dietary curcumin (2000 ppm), but not ibuprofen, suppressed oxidative damage (isoprostane levels) and synaptophysin loss. Both ibuprofen and curcumin reduced microgliosis in cortical layers, but curcumin increased microglial labeling within and adjacent to A beta -ir deposits. In a second group of middle-aged female SD rats, 500 ppm dietary curcumin prevented A beta -infusion induced spatial memory deficits in the Morris Water Maze and post-synaptic density (PSD)-95 loss and reduced A beta deposits. Because of its low side-effect profile and long history of safe use, curcumin may find clinical application for AD prevention. (C) 2001 Elsevier Science Inc. All rights reserved.