Galectin-3 and the skin.
Galectin-3 and the skin.
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DOI：
10.1016/j.jdermsci.2011.07.008
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发表时间：
2011-11
影响因子：
4.6
通讯作者：
Liu FT
中科院分区：
文献类型：
--
作者：
Larsen L;Chen HY;Saegusa J;Liu FT
Galectin-3在包括角质形成细胞在内的上皮细胞中高表达，通过影响免疫细胞的功能参与炎症性皮肤病的发病机制。例如，galectin-3 可通过调节树突状细胞 (DC) 和 T 细胞功能，促进 Th2 免疫反应的极化，从而导致特应性皮炎 (AD)。此外，galectin-3可能通过调节抗原呈递细胞的迁移能力参与接触性超敏反应的发生。 Galectin-3可能通过多种信号通路发挥上皮肿瘤进展和发展的调节作用，例如通过调节细胞外信号调节激酶（ERK）和活化蛋白激酶B（AKT）的激活状态来抑制角质形成细胞凋亡。 Galectin-3 在黑色素瘤发展的不同阶段被检测到。相反，在非黑色素瘤皮肤癌中，例如鳞状细胞癌（SCC）和基底细胞癌（BCC）中观察到半乳糖凝集素-3的表达显着降低。 Galectin-3可能在肿瘤细胞生长、凋亡、细胞运动、侵袭和转移中发挥重要作用。 Galectin-3可能成为多种皮肤病的新治疗靶点。
Galectin-3 is highly expressed in epithelial cells including keratinocytes and is involved in the pathogenesis of inflammatory skin diseases by affecting the functions of immune cells. For example, galectin-3 can contribute to atopic dermatitis (AD) by promoting polarization toward a Th2 immune response by regulating dendritic cell (DC) and T cell functions. In addition, galectin-3 may be involved in the development of contact hypersensitivity by regulating the migratory capacity of antigen presenting cells. Galectin-3 may act as a regulator of epithelial tumor progression and development through various signaling pathways, such as inhibiting keratinocyte apoptosis through regulation of the activation status of extracellular signal-regulated kinase (ERK) and activated protein kinase B (AKT). Galectin-3 is detected at different stages of melanoma development. In contrast, a marked decrease in the expression of galectin-3 is observed in non-melanoma skin cancers, such as squamous cell carcinoma (SCC) and basal cell carcinoma (BCC). Galectin-3 may play an important role in tumor cell growth, apoptosis, cell motility, invasion, and metastasis. Galectin-3 may be a novel therapeutic target for a variety of skin diseases.