Soluble vascular cell adhesion molecule-1 and E-selectin levels in relation to vascular risk factors and to E-selectin genotype in the first degree relatives of NIDDM patients and in NIDDM patients
Soluble vascular cell adhesion molecule-1 and E-selectin levels in relation to vascular risk factors and to E-selectin genotype in the first degree relatives of NIDDM patients and in NIDDM patients
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DOI：
10.1007/s001250050930
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发表时间：
1998-04-01
期刊：
影响因子：
8.2
通讯作者：
Grant, PJ
中科院分区：
文献类型：
--
作者：
Bannan, S;Mansfield, MW;Grant, PJ
为探讨可溶性黏附分子水平与代谢和遗传的关系，测定了60例非胰岛素依赖型糖尿病(NIDDM)患者、60例NIDDM患者一级亲属和60例正常对照的血浆可溶性E-选择素和血管细胞黏附分子-1水平。此外，还确定了编码丝氨酸向精氨酸转变的E-选择素A561C基因型。患者组E-选择素水平为57[52-63](平均[95%可信区间])ng/ml，与两个亲属比较；44[39-50]ng/mlp=0.001，对照组39.5[36-43]ng/mlp=0.0001。各组E-选择素水平与甘油三酯、组织型纤溶酶原激活物及纤溶酶原激活剂抑制物-1活性呈正相关。E-选择素水平与E-选择素基因型有关，携带精氨酸等位基因的受试者E-选择素水平较高(51.4vs44.5 ng/mlp<；0.05)。E-选择素水平在对照组(女性35[32-39]对男性45[40-51]ng/mlp=0.004)和糖尿病亲属(女性38[33-44]对男性52[45-61]ng/mlp=0.004)中高于女性，但在水平相近的非胰岛素依赖型糖尿病患者中无明显差异(女性58[49-69]对男性56[50-62]ng/ml，ns)。可溶性血管细胞黏附分子-1水平在对照组640[598~686]ng/ml、NIDDM亲属634[593~678]ng/ml和NIDDM患者664[608~725]ng/ml之间差异无统计学意义。对照组和患者血管细胞黏附分子-1水平与血管性假血友病因子(VWF)呈正相关。结果表明，对照组、NIDDM亲属和NIDDM患者的E-选择素水平与血管危险因素有关。
To investigate the metabolic and genetic associations of levels of soluble adhesion molecules, plasma levels of soluble E-selectin and vascular cell adhesion molecule-1 were measured in 60 non-insulin-dependent diabetes mellitus (NIDDM) patients, 60 first-degree relatives of NIDDM patients and 60 control subjects, none of whom displayed clinical features of vascular disease. In addition, E-selectin A561C genotype, coding for a serine to arginine change, was determined. E-selectin levels were ele vated in the patient group; 57 [52-63] (mean [95 % confidence intervals]) ng/ml, compared with both relatives; 44 [39-50] ng/ml p = 0.001 and controls 39.5 [36-43] ng/ml p = 0.0001. E-selectin levels correlated with triglycerides, tissue-plasminogen activator and plasminogen activator inhibitor-1 activity in all groups. Levels of E-selectin were related to E-selectin genotype, being higher in subjects possessing the arginine allele (51.4 vs 44.5 ng/ml p < 0.05). E-selectin levels were higher in males than females in controls (female 35 [32-39] vs male 45 [40-51] ng/ml p = 0.004), and NIDDM relatives (female 38 [33-44] vs male 52 [45-61] ng/ml p = 0.004) but not in NIDDM patients where levels were similar (female 58 [49-69] vs male 56 [50-62] ng/ml, ns). There was no difference in soluble vascular cell adhesion molecule-1 levels between the three groups (control 640 [598-686] ng/ml, NIDDM relatives 634 [593-678] ng/ml and NIDDM patients 664 [608-725] ng/ml). In controls and patients vascular cell adhesion molecule-1 levels correlated with von Willebrand factor (vWF). The results indicate that levels of E-selectin relate to vascular risk factors in control subjects, NIDDM relatives and NIDDM patients.