The influence of sex and social isolation housing on pre- and postsynaptic 5-HT1A receptors
The influence of sex and social isolation housing on pre- and postsynaptic 5-HT1A receptors
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DOI：
10.1016/j.brainres.2006.05.051
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发表时间：
2006-08-04
期刊：
影响因子：
2.9
通讯作者：
Oehler, Jochen
中科院分区：
文献类型：
--
作者：
Schiller, Lydia;Jaehkel, Monika;Oehler, Jochen
5-羟色胺（5-HT）受体对于不同的脑功能是至关重要的，并且在一些病理状况中起重要作用。我们分析了[H-3]8-OH-DPAT-特异性结合5-HT 1A受体的雄性和雌性小鼠后组或隔离住房在体外放射自显影（n = 6每组）。女性表现出较高的突触后5-HT 1A受体结合相比，男性，特别是在皮层。相反，在雌性海马中发现较低的[H-3]8-OH-DPAT特异性结合。体树突5-HT 1A自身受体无性别差异。突触后5-HT 1A受体结合的性别差异应与行为性别差异有关，特别是在自发活动和视神经依赖行为方面。六周的隔离住房造成的5-HT 1A受体结合在大多数分析的大脑区域的增加，在男性更明显。在单独的雄性动物中，在海马CA 1区（+16.8%）、隔区（+76.8%）、皮质杏仁核（+24.6%）、导水管周围灰质（+67.2%）和分析的不同皮质区域（+61.8-81.4%）中检测到增加。[H-3]8-OH-DPAT特异性结合在离体雌性动物的齿状回（+47.1%）、杏仁上核（+31.2%）和下丘脑腹内侧（+34.4%）中显著增加。在中缝核中也发现了性别依赖性隔离诱导的[H-3]8-OH-DPAT特异性结合的改变。隔离诱导的5-HT 1A受体结合增加可能与隔离物中经常观察到的具有增强的唤醒、冲动和活动的行为去抑制有关。雄性特有的皮质边缘系统和中脑的改变可能对隔离诱导的攻击性至关重要。脑研究（c）2006由Elsevier B. V.出版。
Serotonergic (5-HT) receptors are crucial for different brain functions and play an important role in several pathological conditions. We analysed [H-3]8-OH-DPAT-specific binding to 5-HT1A receptors in male and female mice after group or isolation housing by in vitro autoradiography (n = 6 per group). Females displayed higher postsynaptic 5-HT1A receptor binding compared to males, especially in the cortex. in contrast, lower [H-3]8-OH-DPATspecific binding was found in the female hippocampus. No sex difference was seen for the somatodendritic 5-HT1A autoreceptor. Sex differences in postsynaptic 5-HT1A receptor binding should be relevant to behavioural sex differences, especially in locomotor activity and hippocampus-dependent behaviours. Six weeks isolation housing caused an increase in 5-HT1A receptor binding in most of the brain regions analysed and was more pronounced in males. In isolated males, the increases were detected in the CA1 field of the hippocampus (+16.8%), in the septum (+76.8%), in the cortical amygdala (+24.6%), in the periaqueductal gray (+67.2%) and in the different cortical regions analysed (+61.8-81.4%). [H-3]8-OH-DPATspecific binding increased significantly in the dentate gyrus (+47.1%), the supramarnmillary nucleus (+31.2%) and in the ventromedial hypothalamus (+34.4%) of isolated females. Sex-dependent isolation -induced alterations in [H-3]8-OH-DPAT-specific binding were also found in the raphe nuclei. Isolation -induced increases in 5-HT1A receptor binding could be relevant to the behavioural disinhibition with heightened arousal, impulsivity and activity often observed in isolates. The male-specific alterations in the corticolimbic system as well as in the midbrain could be crucial for isolation-induced aggression. BRAIN RESEARCH (c) 2006 Published by Elsevier B.V.