Prevention of infections in patients with neoplastic disease: use of a historical model for developmental strategies.
Prevention of infections in patients with neoplastic disease: use of a historical model for developmental strategies.
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预防肿瘤疾病患者的感染：使用历史模型制定发展策略。
DOI：
10.1093/clinids/17.supplement_2.s355
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发表时间：
1993
期刊：
影响因子：
--
通讯作者：
White,MH
中科院分区：
文献类型：
--
作者：
White,MH
与肿瘤性疾病相关的感染及其治疗已被充分描述。特定感染和特定免疫缺陷之间的关联也已被定义。尽管意识到某些患者群体处于风险中，但尚未研究许多这些感染的潜在预防方案。综述了异烟肼在结核病预防中的应用进展。并以此为例讨论了肿瘤性疾病预防性抗生素研究的要求。与肿瘤性疾病相关的特定感染被建议作为预防方案的多中心对照试验的候选者。
Infections associated with neoplastic disease and its treatment are well described. Associations between specific infections and particular immune defects have also been defined. Despite the awareness that certain patient populations are at risk, potential prophylactic regimens for many of these infections have not been studied. The development of isoniazid for the prevention of tuberculosis is reviewed. The requirements for the study of prophylactic antibiotics in patients with neoplastic disease are discussed based on this example. Specific infections associated with neoplastic disease are suggested as candidates for multicenter controlled trials of prophylactic regimens.