Epithelial membrane antigen expression by the perineurium of peripheral nerve and in peripheral nerve tumours
Epithelial membrane antigen expression by the perineurium of peripheral nerve and in peripheral nerve tumours
复制标题
周围神经神经束膜和周围神经肿瘤中上皮膜抗原的表达
作者：
J. Theaker;K. Gatter;J. Puddle
用三种不同的抗上皮膜抗原（EMA）单克隆抗体对正常周围神经和一系列周围神经病变标本进行免疫染色。EMA免疫反应性的位点已被证实在周围神经的神经束膜细胞内，在神经鞘瘤和栅栏状包裹的神经瘤的包膜内注意到，并且也在创伤性神经瘤和丛状神经纤维瘤中检测到。在单纯性神经纤维瘤、弥漫性神经纤维瘤和恶性神经鞘瘤中未检测到表达。EMA表达的这些部位与神经束膜细胞参与特定病变的形成相一致。EMA表达的神经束膜和piaarachnoid膜之间的关系进行了讨论。
Specimens of normal peripheral nerve and a series of peripheral nerve lesions have been immunostained with three different anti‐epithelial membrane antigen (EMA) monoclonal antibodies. Sites of EMA immunoreactivity have been confirmed within perineurial cells of peripheral nerve, noted within the capsule of Schwannomas and palisaded encapsulated neuromas, and also detected with traumatic neuromas and plexiform neurofibromas. No expression was detected within simple neurofibromas, diffuse neurofibromas or within malignant Schwannomas. These sites of EMA expression concur with the suggested involvement of perineurial cells in the formation of the particular lesions. The relationship between EMA expression by the perineurium and the piaarachnoid membrane is discussed.
免疫过氧化物酶组织化学在人类神经肿瘤学中的最新应用。
影响因子：
4.6
作者：
Perentes,E;Rubinstein,LJ
通讯作者：
Rubinstein,LJ