Pilot trial of nicotine patches as an alternative to corticosteroids in ulcerative colitis
Pilot trial of nicotine patches as an alternative to corticosteroids in ulcerative colitis
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DOI：
10.1007/bf02355071
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发表时间：
1996-08-01
影响因子：
6.3
通讯作者：
Tittobello, A
中科院分区：
文献类型：
--
作者：
Guslandi, M;Tittobello, A
10 名在美沙拉嗪 (Ig ti.d.) 治疗期间出现轻度至中度溃疡性结肠炎临床复发且既往有类固醇耐受性较差病史的患者，加用透皮尼古丁（每日 15 mg），持续 4 周。通过采用 Rachmilewitz 活动指数来评估临床结果。其中 7 名患者获得了临床缓解，且在尼古丁戒断后效果可持续长达 3 个月。进行内窥镜和组织学检查后，证实了临床发现。对于某些患有轻度至中度溃疡性结肠炎复发的患者，尼古丁贴片可能是类固醇的良好替代品。确切的作用机制仍不清楚。
In ten patients with mild to moderate clinical relapses of ulcerative colitis during treatment with mesalazine (Ig t.i.d.) and with a previous history of poorly tolerated steroid courses, transdermal nicotine (15 mg daily) was added for 4 weeks. Clinical findings were assessed by employing Rachmilewitz's activity index. In 7 of the patients, clinical remission was achieved, the results persisting for up to 3 months after nicotine withdrawal. Endoscopic and histological examination, when performed, confirmed the clinical findings. Nicotine patches may represent a good alternative to steroids in selected patients with mild to moderate relapses of ulcerative colitis. The precise mechanism of action remains unknown.