A novel and compact review on the role of oxidative stress in female reproduction.
A novel and compact review on the role of oxidative stress in female reproduction.
复制标题
关于氧化应激在女性生殖中的作用的新颖而紧凑的综述
DOI：
10.1186/s12958-018-0391-5
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发表时间：
2018-08-20
期刊：
影响因子：
--
通讯作者：
Dong Y
中科院分区：
文献类型：
--
作者：
Lu J;Wang Z;Cao J;Chen Y;Dong Y
近年来，氧化应激（OS）的研究日益受到关注。特别是，OS对女性生育能力的作用非常重要，一直受到密切关注。OS的发生是由于活性氧（ROS）的过量产生。ROS是一把双刃剑；它们不仅在许多细胞内信号级联反应中作为次级信使发挥重要作用，而且在涉及女性生殖道的病理过程中也发挥着不可或缺的作用。活性氧和抗氧化剂参与调节动物和人类的生殖过程。促氧化剂和抗氧化剂之间的不平衡可能导致许多女性生殖疾病。本文就OS的发生机制及一系列女性生殖过程进行综述，阐述OS在女性生殖中的作用以及由OS引起的女性生殖疾病，包括多囊卵巢综合征（PCOS）、子宫内膜异位症、先兆子痫等。描述了受OS影响的Keap1-Nrf2、NF-κB、FOXO、MAPK等多种参与女性生殖的信号通路，为生殖疾病的发病机制提供了新的思路。
In recent years, the study of oxidative stress (OS) has become increasingly popular. In particular, the role of OS on female fertility is very important and has been focused on closely. The occurrence of OS is due to the excessive production of reactive oxygen species (ROS). ROS are a double-edged sword; they not only play an important role as secondary messengers in many intracellular signaling cascades, but they also exert indispensable effects on pathological processes involving the female genital tract. ROS and antioxidants join in the regulation of reproductive processes in both animals and humans. Imbalances between pro-oxidants and antioxidants could lead to a number of female reproductive diseases. This review focuses on the mechanism of OS and a series of female reproductive processes, explaining the role of OS in female reproduction and female reproductive diseases caused by OS, including polycystic ovary syndrome (PCOS), endometriosis, preeclampsia and so on. Many signaling pathways involved in female reproduction, including the Keap1-Nrf2, NF-κB, FOXO and MAPK pathways, which are affected by OS, are described, providing new ideas for the mechanism of reproductive diseases.
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影响因子：
64.5
作者：
Brunet, A;Bonni, A;Greenberg, ME
通讯作者：
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