Nature‐Inspired Construction of MOF@COF Nanozyme with Active Sites in Tailored Microenvironment and Pseudopodia‐Like Surface for Enhanced Bacterial Inhibition
Nature‐Inspired Construction of MOF@COF Nanozyme with Active Sites in Tailored Microenvironment and Pseudopodia‐Like Surface for Enhanced Bacterial Inhibition
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受自然启发构建 MOF@COF 纳米酶，在定制的微环境和伪足样表面中具有活性位点，以增强细菌抑制作用
DOI：
10.1002/anie.202012487
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发表时间：
2020
期刊：
影响因子：
--
通讯作者：
Xiaogang Qu
中科院分区：
文献类型：
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作者：
Lu Zhang;Zhengwei Liu;Qingqing Deng;Yanjuan Sang;Kai Dong;Jinsong Ren;Xiaogang Qu
金属有机框架（MOFs）引起了人们对模拟天然酶结构和功能的兴趣。然而，由于相对较低的催化活性，它们的催化和治疗效率不令人满意。在此，受自然界的启发，M0F@COF纳米酶被设计为高效过氧化物酶模拟物，其中M0 F的金属节点作为活性中心，通过共价有机框架（COF）的生长产生的分级纳米腔作为结合口袋，以在活性位点周围形成定制的孔微环境，用于富集和活化底物分子，以执行增强的细菌抑制。此外，COF“皮肤”的伪足样表面使系统能够有效地捕获细菌，以进一步放大基于MOF的纳米酶的治疗效率。我们相信，本研究不仅有助于设计新的纳米酶，而且还拓宽了基于MOF/COF的杂化材料的生物用途。
Metal–organic frameworks (MOFs) have sparked increasing interest in mimicking the structure and function of natural enzymes. However, their catalytic and therapeutic efficiency are unsatisfactory due to the relatively lower catalytic activity. Herein, inspired by nature, a MOF@COF nanozyme has been designed as a high‐efficiency peroxidase mimic, with the metallic nodes of MOFs as active centres, the hierarchical nanocavities produced by the growth of covalent organic frameworks (COFs) as binding pockets to form tailored pore microenvironment around active sites for enriching and activating substrate molecules, to perform enhanced bacterial inhibition. Furthermore, the pseudopodia‐like surface of the COFs “skin” enabled the system to catch the bacteria effectively for further amplifying the therapeutic efficiency of MOF‐based nanozyme. We believe that the present study will not only facilitate the design of novel nanozymes, but also broaden the biological usage of MOF/COF‐based hybrid materials.