Oligoclonal band number as a marker for prognosis in multiple sclerosis
Oligoclonal band number as a marker for prognosis in multiple sclerosis
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DOI：
10.1001/archneur.58.12.2044
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发表时间：
2001-12-01
影响因子：
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通讯作者：
Trotter, JL
中科院分区：
文献类型：
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作者：
Avasarala, JR;Cross, AH;Trotter, JL
多发性硬化症的自然病程各不相同。临床表现明显但随着时间的推移导致的残疾很小的多发性硬化症被标记为良性多发性硬化症。在临床和其他支持性数据的基础上预测多发性硬化症的后续临床病程的能力将是非常宝贵的。在这篇文章中，我们报告了基于1800例多发性硬化症患者的回顾性分析结果，其中44例患者符合我们的纳入标准。有一种提示，诊断时脑脊液中寡克隆条带数量少或缺失预示着较好的预后。然而，脑脊液中寡克隆带的定量仍然是一个不敏感的预后指标，不能用于影响治疗方案的决定。
The natural course of disease in multiple sclerosis varies. Multiple sclerosis that is clinically apparent but causes minimal disability over time has been labeled benign multiple sclerosis. The ability to predict the subsequent clinical course of multiple sclerosis on the basis of clinical and other supportive data at presentation would be invaluable. In this article we report our findings based on a retrospective analysis of 1800 patients diagnosed as having multiple sclerosis, of which 44 patients met our inclusion criteria. There was a suggestion that a low or absent number of oligoclonal bands in the cerebrospinal fluid at the time of diagnosis predicts a better prognosis. However, quantification of oligoclonal bands in cerebrospinal fluid remains an insensitive prognostic indicator and must not be used to influence decisions regarding therapeutic options.