Paraproteinemia and Reticulum Cell Sarcoma in an Inbred Mouse Strain
Paraproteinemia and Reticulum Cell Sarcoma in an Inbred Mouse Strain
复制标题
近交系小鼠品系中的副蛋白血症和网状细胞肉瘤
作者：
H. Wanebo;W. Gallmeier;E. A. Boyse;L. Old
近交系SJL/J小鼠具有影响几种细胞类型（包括网状细胞和浆细胞）的增殖性疾病的高发病率，其通常伴有γ1和γ2副蛋白血症。只有在某些情况下才能获得可连续移植的肿瘤细胞系，这些是网状细胞肉瘤。移植网状细胞瘤的小鼠没有副蛋白血症，但可能发生严重的低丙种球蛋白血症。这种疾病可以被视为一种异常增殖的网状细胞分化成浆细胞，随之而来的副蛋白血症;随后出现的可移植网状细胞肉瘤出现作为一个最终阶段，其中这种能力的分化是丢失。
Mice of the inbred SJL/J strain have a high incidence of a proliferative disease affecting several cell types, including reticulum cells and plasma cells, which is frequently accompanied by γ1 and γ2 paraproteinemia. In only some instances can seriallytransplantable lines of neoplastic cells be obtained; these are reticulum cell sarcomas. Mice with transplanted reticulum cell e arcomas do not have paraproteinemia and may develop profound hypogammaglobulinemia. The disease may be viewed as an abnormal proliferation of reticulum cells which differentiate into plasma cells with consequent paraproteinemia; the subsequent emergence of transplantable reticulum cell sarcoma appears as an end stage in which this capacity to differentiate is lost.