Effects of stimulus sequence on event-related potentials and reaction time during target detection in Alzheimer's disease
Effects of stimulus sequence on event-related potentials and reaction time during target detection in Alzheimer's disease
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DOI：
10.1016/s1388-2457(00)00332-1
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发表时间：
2000-08-01
影响因子：
4.7
通讯作者：
Starr, A
中科院分区：
文献类型：
--
作者：
Golob, EJ;Starr, A
目的：在阿尔茨海默病 (AD) 的听觉目标检测范例中检查诱发电位和行为作为刺激序列的函数。方法：从 12 名健康老年对照者和 10 名轻度 AD 患者中收集诱发电位和反应时间。受试者按下对高音目标音调（P = 0.20）的响应按钮，这些目标音调与低音调频繁音调随机混合。我们测量了刺激前准备电位 (RP)、事件相关电位（P50、N100、P200、N200 和 P300）以及作为刺激序列函数的反应时间。 结果：AD 受试者的准确度水平与对照组相当，但反应时间显着增加。 AD 中的总平均电位显示 RP 振幅显着降低，P300 潜伏期增加。对照组和 AD 均表现出反应时间加快、RP 幅度增加以及 P300 潜伏期减少，作为目标之前的频繁频率数量的函数。在对照组中发现了其他成分（P200 和 N200）的顺序变化，但在 AD 中未发现。结论：AD 患者的 RT 和某些诱发电位成分随着刺激序列的变化而发生系统性变化。尽管总体表现和预期（RP）和刺激分类（P300潜伏期）的诱发电位测量是异常的，但目标预期的每时每刻的变化在很大程度上保留了下来。 (C) 2000 Elsevier Science Ireland Ltd. 保留所有权利。
Objectives: To examine evoked potentials and behavior as a function of stimulus sequence in an auditory target detection paradigm in Alzheimer's disease (AD).Methods: Evoked potentials and reaction times were collected from 12 healthy elderly controls and 10 patients with mild AD. Subjects pressed a response button to high-pitched target tones (P = 0.20) that were randomly intermixed with low-pitched frequent tones. We measured pre-stimulus readiness potential (RP), event-related potentials (P50, N100, P200, N200 and P300), and reaction time as a function of the stimulus sequence.Results: AD subjects performed at comparable levels of accuracy as controls, but had significantly increased reaction times. Grand averaged potentials in AD showed a significant reduction of the amplitude of the RP, and an increase of P300 latency. Both controls and AD showed speeding of reaction time, increases in RP amplitude, and decreases in P300 latency as a function of the number of frequents preceding the target. Sequential changes of other components (P200 and N200) were found in controls but not AD.Conclusions: AD patients have systematic changes of both RT and certain of the evoked potential components as a function of stimulus sequence. Moment-by-moment changes in target expectancy are largely preserved in AD, even though overall performance and evoked potential measures of expectancy (RP) and stimulus classification (P300 latency) are abnormal. (C) 2000 Elsevier Science Ireland Ltd. All rights reserved.