On the selective killing of cold atmospheric plasma cancer treatment: Status and beyond
On the selective killing of cold atmospheric plasma cancer treatment: Status and beyond
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DOI：
10.1002/ppap.202100020
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发表时间：
2021-08
影响因子：
3.5
通讯作者：
D. Yan;Alex Horkowitz;Qihui Wang;M. Keidar
中科院分区：
文献类型：
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作者：
D. Yan;Alex Horkowitz;Qihui Wang;M. Keidar
与许多化疗和放疗方式相比，选择性杀死癌细胞是冷大气等离子体（CAP）的关键特征。了解其潜在机制将为基于 CAP 的癌症治疗奠定基础。此外，我们提供了前瞻性思维，将选择性的定义从涉及单细胞系的传统案例扩展到共培养案例。最后，新建立的基于物理的治疗策略提供了前所未有的愿景，以实现超越先前建立的基于活性物质和直接杀伤效应的概念的选择性。
Compared with many chemotherapy and radiotherapy modalities, selective killing of cancer cells is a pivotal feature of cold atmospheric plasma (CAP). Understanding its underlying mechanism will build the foundation of CAP‐based cancer treatment. Additionally, we provided forward‐looking thinking to extend the definition of selectivity from conventional cases involving a single‐cell line to a coculture case. Finally, the newly established physically based treatment strategy provides unprecedented visions to realize selectivity beyond the previously established concepts based on reactive species and direct killing effect.