Binding of Streptococcus mutans to extracellular matrix molecules and fibrinogen
Binding of Streptococcus mutans to extracellular matrix molecules and fibrinogen
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DOI：
10.1016/s0006-291x(02)02390-2
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发表时间：
2002-10-18
影响因子：
3.1
通讯作者：
Holt, RG
中科院分区：
文献类型：
--
作者：
Beg, AM;Jones, MN;Holt, RG
我们已经确定了变形链球菌细胞与细胞外基质（ECM）分子和纤维蛋白原结合的能力。S.发现变形细胞结合纤连蛋白、层粘连蛋白、I型胶原和纤维蛋白原。一个等基因S.变形链球菌主要表面蛋白表达缺陷的菌株。变形链球菌抗原I/II与纤连蛋白、胶原蛋白和纤维蛋白原结合能力降低，但与层粘连蛋白结合能力降低，提示抗原I/II在病理过程中参与了变形链球菌的相互作用。具有纤连蛋白、I型胶原和纤维蛋白原的变异细胞。(C)2002 Elsevier Science（美国）。All rights reserved.
We have determined the ability of Streptococcus mutans cells to bind to extracellular matrix (ECM) molecules and fibrinogen. S. mutans cells were found to bind fibronectin, laminin, collagen type I, and fibrinogen. An isogenic S. mutans strain with a defect in the expression of the major surface protein of S. mutans, antigen I/II, possessed a reduced ability to bind fibronectin, collagen, and fibrinogen but not laminin, suggesting that antigen I/II contributes during pathological processes to the interaction of S. mutans cells with fibronectin, collagen type I, and fibrinogen. (C) 2002 Elsevier Science (USA). All rights reserved.