Elevated maternal androgen is associated with dysfunctional placenta and lipid disorder in newborns of mothers with polycystic ovary syndrome
Elevated maternal androgen is associated with dysfunctional placenta and lipid disorder in newborns of mothers with polycystic ovary syndrome
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母体雄激素升高与多囊卵巢综合征母亲的新生儿胎盘功能障碍和血脂紊乱有关
DOI：
10.1016/j.fertnstert.2020.02.005
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发表时间：
2020-06-01
影响因子：
6.7
通讯作者：
Hou, Lihui
中科院分区：
文献类型：
--
作者：
Sun, Miao;Sun, Bo;Hou, Lihui
目的：探讨多囊卵巢综合征（PCOS）妇女及其新生儿胎盘形态改变及临床特点。我们招募了患有PCOS的孕妇（n = 12）和未患有PCOS的孕妇（n = 11）。分娩后采集胎盘、母体血和脐带血。设计：临床观察性研究。设置：不适用。患者：本研究于2015年2月至2015年10月在中国黑龙江中医药大学第一附属医院妇产科门诊就诊的PCOS孕妇和健康孕妇。干预:没有。主要结局指标：对PCOS女性和健康女性的胎盘进行蛋白质组学分析。结果：PCOS组母鼠睾酮、雄烯二酮、硫酸脱氢表雄酮、游离雄激素指数、胆固醇、载脂蛋白B、载脂蛋白B/载脂蛋白A-I水平均显著高于对照组，子代PCOS组的硫酸脱氢表雄酮、高密度脂蛋白、胆固醇水平均显著高于对照组。与对照组相比，PCOS组胎盘表现为梗死、钙化和更大的绒毛间隙。与未患多囊卵巢综合征的妇女相比，多囊卵巢综合征妇女胎盘中雌激素受体- β蛋白水平较高。将PCOS组与对照组进行比较，发现胎盘中有258种蛋白存在显著差异，其中纤连蛋白1与其他差异蛋白的关系最为密切。结论：过度暴露于高雄激素血症和高脂血症影响胎盘功能，与新生儿代谢障碍的发生有关。(C) 2020年美国生殖医学学会。)
Objective: To investigate the placental morphology alterations and identify the clinical characteristics of women with polycystic ovary syndrome (PCOS) and their newborns. Pregnant women with PCOS (n = 12) and pregnant women without PCOS (n = 11) were recruited. Then, the placenta, maternal blood and cord blood were collected after delivery.Design: Clinical observational study.Setting: Not applicable. Patient(s): In the present study, pregnant women with PCOS and healthy pregnant women were recruited from the clinic of the Department of Obstetrics and Gynecology, First Affiliated Hospital, Heilongjiang University of Chinese Medicine, China, between February 2015 and October 2015.Intervention(s): None.Main Outcome Measure(s): A proteomic analysis was performed on the placenta in women with PCOS and healthy women.Result(s): The maternal testosterone, androstenedione, dehydroepiandrosterone sulfate, free androgen index, cholesterol, apolipoprotein B, and apolipoprotein B/apolipoprotein A-I levels were significantly higher in the PCOS group than in the control group, and the offspring in the PCOS group had higher dehydroepiandrosterone sulfate, high-density lipoprotein, and cholesterol levels, when compared with the control group. The placenta in the PCOS group demonstrated infarction, calcification, and a greater intervillous space, when compared with the control group. A higher level of estrogen receptor-beta protein was observed in the placenta of women with PCOS, when compared with women without PCOS. A total of 258 proteins in the placenta were identified to be significantly different, when the PCOS and control groups were compared, and fibronectin 1 exhibited the closest relationship with other differential proteins.Conclusion(s): The overexposure to hyperandrogenism and hyperlipidemia affects the functions of the placenta, which are associated with the development of metabolic disorders in newborns. ((C) 2020 by American Society for Reproductive Medicine.)