Functional organization of ferret auditory cortex
Functional organization of ferret auditory cortex
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DOI：
10.1093/cercor/bhi042
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发表时间：
2005-10-01
期刊：
影响因子：
3.7
通讯作者：
King, AJ
中科院分区：
文献类型：
--
作者：
Bizley, JK;Nodal, FR;King, AJ
我们的特点是不同领域内的听觉皮层麻醉雪貂的功能组织。如前所述，初级听觉皮层，A1，和前听觉领域，AAF，位于中间外侧回。这些地区表现出类似的tonotopic组织，高频率的背侧尖的脑回和低频率更腹侧，但不同的是，AAF神经元有较短的响应lavelian比那些在A1。在频率选择性，时间响应特性和阈值的差异的基础上，我们确定了四个以前未描述的领域。其中两个位于外侧裂后回上，并进行了tonotopically组织。在这些领域的神经元反应强劲的音调，但更长的lavelian，更持续的反应和更高的发病率的非单调率水平的功能比那些在主要领域。两个进一步的听觉领域，这是不tonotopically组织，被发现在前外侧回。在更背侧的前区的神经元给予短潜伏期，短暂的反应，音调和一般广泛的调谐与高（> 8 kHz）频率的偏好。其他前区的神经元经常对音调没有反应，但经常对宽带噪声做出强烈反应。存在的tonotopic和non-tonotopic听觉皮层领域表明，雪貂听觉皮层的组织是在其他哺乳动物中看到的。
We characterized the functional organization of different fields within the auditory cortex of anaesthetized ferrets. As previously reported, the primary auditory cortex, A1, and the anterior auditory field, AAF, are located on the middle ectosylvian gyrus. These areas exhibited a similar tonotopic organization, with high frequencies represented at the dorsal tip of the gyrus and low frequencies more ventrally, but differed in that AAF neurons had shorter response latencies than those in A1. On the basis of differences in frequency selectivity, temporal response properties and thresholds, we identified four more, previously undescribed fields. Two of these are located on the posterior ectosylvian gyrus and were tonotopically organized. Neurons in these areas responded robustly to tones, but had longer latencies, more sustained responses and a higher incidence of non-monotonic rate-level functions than those in the primary fields. Two further auditory fields, which were not tonotopically organized, were found on the anterior ectosylvian gyrus. Neurons in the more dorsal anterior area gave short-latency, transient responses to tones and were generally broadly tuned with a preference for high (> 8 kHz) frequencies. Neurons in the other anterior area were frequently unresponsive to tones, but often responded vigorously to broadband noise. The presence of both tonotopic and non-tonotopic auditory cortical fields indicates that the organization of ferret auditory cortex is comparable to that seen in other mammals.