Asymmetrical diffusion tensor imaging indices of the rostral substantia nigra in Parkinson's disease
Asymmetrical diffusion tensor imaging indices of the rostral substantia nigra in Parkinson's disease
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DOI：
10.1016/j.parkreldis.2012.05.021
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发表时间：
2012-11-01
影响因子：
4.1
通讯作者：
Au, Wing Lok
中科院分区：
文献类型：
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作者：
Prakash, Bhaskaran David;Sitoh, Yih-Yian;Au, Wing Lok
目的：帕金森病（PD）的运动不对称在临床和功能性神经影像学上很明显，但在弥散张量成像（DTI）中没有报道。方法：对11例PD患者和12例健康对照者进行DTI扫描，观察PD患者黑质各向异性分数（FA）和表观扩散系数（ADC）的不对称性。由2名独立评定者在每侧SN的尾侧、中间和吻侧绘制感兴趣区（ROI）。结果：PD患者头侧SN的FA（p < 0.005）和ADC（p < 0.00005）具有明显的不对称性。PD组与正常对照组之间的左、右吻侧SN的FA和ADC值差异有统计学意义，分别为p < 0.05和p < 0.02。PD患者在左吻侧SN的ADC值显著高于健康受试者（p < 0.01）。结论：帕金森病患者头侧SN的DTI指标存在不对称性，头侧SN的FA值与统一帕金森病评定量表（UnitedParkinson 'sDiseaserRatingScale，DMRS）运动评分呈显著正相关（r = 0.7，p < 0.03）。研究了SN中FA与运动功能评分的关系。我们的研究结果可以提供一个模型，更好地理解FA减少的SN的含义。(C)2012爱思唯尔有限公司保留所有权利。
Objective: Motor asymmetry in Parkinson's disease (PD) is evident clinically and on functional neuroimaging, but not reported in diffusion tensor imaging (DTI). We aim to determine if asymmetry in fractional anisotropy (FA) and apparent diffusion coefficient (ADC) can be detected in the substantia nigra (SN) of PD subjects.Methods: DTI scans were performed on 11 PD and 12 healthy subjects. Regions of interest (ROIs) were drawn by 2 independent raters at the caudal, middle and rostral SN on each side. FA and ADC were extracted from the ROIs.Results: Significant asymmetry was observed in the FA (p < 0.005) and ADC (p < 0.00005) at the rostral SN of PD subjects. The differences in FA and ADC across the left and right rostral SN were significantly different between PD and healthy subjects, p < 0.05 and p < 0.02 respectively. PD subjects had significantly higher ADC at the left rostral SN than healthy subjects (p < 0.01). Significant correlation between the Unified Parkinson's Disease Rating Scale (UPDRS) motor scores and the FA was noted in the left rostral SN (r = 0.7, p < 0.03).Conclusions: Asymmetry in DTI indices was noted at the rostral SN of PD subjects. The relationship between FA in the SN and UPDRS motor score was studied. Our findings may provide a model for better understanding of the implication of FA reduction in the SN. (C) 2012 Elsevier Ltd. All rights reserved.