One small mouse step for man.
One small mouse step for man.
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人类的一小步。
DOI：
10.1016/j.kint.2021.11.002
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发表时间：
2022
影响因子：
19.6
通讯作者：
Tan,RoderickJ
中科院分区：
文献类型：
--
作者：
Tan,RoderickJ
太空飞行对肾功能的影响需要进一步研究。核因子红细胞2相关因子2敲除小鼠成为第一个被送入轨道并活着返回地球的基因工程菌株。在这一期中，Suzukiet等人提供了这些基因敲除和野生型小鼠的肾脏分析。所有的航天小鼠都表现出基因变化，可以抑制活性维生素D的水平，并增加血压。核因子红系2相关因子2可能改变脂质排泄和代谢相关基因的表达。
The effect of spaceflight on kidney function requires additional study. The nuclear factor erythroid 2-related factor 2 knockout mouse became the first genetically engineered strain sent into orbit and to return to earth alive. In this issue, Suzukiet al.provide kidney analyses of these knockout and wild-type mice. All spaceflight mice exhibited gene changes that could suppress levels of active vitamin D and increase blood pressure. Nuclear factor erythroid 2-related factor 2 may alter expression of genes related to lipid excretion and metabolism.