The Role and Function of Fcγ Receptors on Myeloid Cells
The Role and Function of Fcγ Receptors on Myeloid Cells
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DOI：
10.1128/microbiolspec.mchd-0045-2016
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发表时间：
2016-12-01
影响因子：
3.7
通讯作者：
Ravetch, Jeffrey V.
中科院分区：
文献类型：
--
作者：
Bournazos, Stylianos;Wang, Taia T.;Ravetch, Jeffrey V.
生物体存活的一个关键决定因素是它们识别和有效应答外来抗原的能力。这在很大程度上是通过免疫系统的先天和适应性分支的协调活动来实现的。抗体是针对外来抗原特异性产生的，从而促进了对几乎无限多样性的抗原的特异性识别。抗体Fc结构域特异性受体（Fc受体）在各种髓样白细胞群体的表面上表达，并介导先天性白细胞对抗体的结合和识别。通过直接连接免疫的先天性和适应性组分，Fc受体通过诱导由Fc结构域接合后启动的多种促炎、抗炎和免疫调节过程，在宿主防御和维持组织稳态中发挥核心作用。在这一章中，我们讨论的机制，调节Fc结构域结合的各种类型的Fc受体，并提供了一个概述的惊人的多样性的效应器功能，通过对骨髓细胞的Fc-FcR相互作用介导。最后，我们讨论了Fc受体介导的相互作用的背景下IgG介导的炎症，自身免疫，感染的易感性，和抗体为基础的治疗反应的影响。
A key determinant for the survival of organisms is their capacity to recognize and respond efficiently to foreign antigens. This is largely accomplished by the orchestrated activity of the innate and adaptive branches of the immune system. Antibodies are specifically generated in response to foreign antigens, facilitating thereby the specific recognition of antigens of almost infinite diversity. Receptors specific for the Fc domain of antibodies, Fc receptors, are expressed on the surface of the various myeloid leukocyte populations and mediate the binding and recognition of antibodies by innate leukocytes. By directly linking the innate and the adaptive components of immunity, Fc receptors play a central role in host defense and the maintenance of tissue homeostasis through the induction of diverse proinflammatory, anti-inflammatory, and immunomodulatory processes that are initiated upon engagement by the Fc domain. In this chapter, we discuss the mechanisms that regulate Fc domain binding to the various types of Fc receptors and provide an overview of the astonishing diversity of effector functions that are mediated through Fc-FcR interactions on myeloid cells. Lastly, we discuss the impact of FcR-mediated interactions in the context of IgG-mediated inflammation, autoimmunity, susceptibility to infection, and responsiveness to antibody-based therapeutics.