Genetic control of murine IgD structural heterogeneity.
Genetic control of murine IgD structural heterogeneity.
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小鼠 IgD 结构异质性的遗传控制。
DOI：
10.1073/pnas.77.7.4256
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发表时间：
1980
影响因子：
11.1
通讯作者：
Mescher,MF
中科院分区：
文献类型：
--
作者：
Pollock,RR;Dorf,ME;Mescher,MF
鼠B淋巴细胞表达两种天然形式的表面IgD：IgDI由两条δ重链和两条轻链组成; IgDII由一条重链和一条轻链组成。发现存在于脾细胞上的IgDI和IgDII的相对量在不同品系的小鼠之间显著不同。遗传学证据表明IgDI/IgDII比值与Igh-5同种异型相关。(Theδ重链是Igh-5基因座的产物）。携带Igh-5e同种异型的小鼠具有低比率，而携带Igh-5a或Igh-5 b同种异型的小鼠具有高比率。Igh-5基因座和控制IgDI/IgDII比率的基因似乎映射到Igh-6和Igh-V基因座之间的区域。
Murine B lymphocytes express two native forms of surface IgD: IgDI consists of two delta heavy chains and two light chains; IgDII consists of one heavy chain and one light chain. The relative amounts of IgDI and IgDII present on spleen cells were found to vary significantly among different strains of mice. Genetic evidence demonstrated that the IgDI/IgDII ratio is linked to the Igh-5 allotype. (The delta heavy chain is the product of the Igh-5 locus). Mice bearing the Igh-5e allotype have a low ratio, and mice bearing the Igh-5a or Igh-5b allotype have a high ratio. The Igh-5 locus and the gene controlling the IgDI/IgDII ratio appear to map to the region between the Igh-6 and Igh-V loci.