Spontaneous abortion as a screening device. The effect of fetal survival on the incidence of birth defects.
Spontaneous abortion as a screening device. The effect of fetal survival on the incidence of birth defects.
复制标题
自然流产作为筛查手段。
DOI：
10.1093/oxfordjournals.aje.a112163
复制
发表时间：
1975
影响因子：
5
通讯作者：
J. Kline
中科院分区：
文献类型：
--
作者：
Z. Stein;M. Susser;D. Warburton;J. Wittes;J. Kline
To make sound inferences about the distribution, causes and risks of congenital anomalies requires an understanding of selective survival among fetuses. Studies of spontaneous abortions are therefore advocated. A simple model is proposed of the distribution, among spontaneous abortions and births, of conceptuses with and without anomalies. The resulting equation accomodates both maternal and fetal factors. Interaction between maternal and fetal factors is hypothesized, in the form of a maternal device for screening out anomalous conceptuses. A number of the known facts about congenital anomalies are shown to be plausibly interpreted in terms of the proposed model. Finally, some clinical and epidemiologic implications of the model for the study of spontaneous abortions are pointed out.
