Ion channels and drug transporters as targets for anthelmintics.
Ion channels and drug transporters as targets for anthelmintics.
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DOI：
10.1007/s40588-014-0007-6
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发表时间：
2014-12
影响因子：
5.2
通讯作者：
Greenberg, Robert M
中科院分区：
文献类型：
--
作者：
Greenberg, Robert M
寄生蠕虫（如寄生虫和土传线虫）的感染非常普遍，并造成了与被忽视的热带病相关的全球健康和经济负担的主要部分。此外，这些寄生虫中的许多感染牲畜和农业中使用的植物，导致进一步的寄生。这些病原体的治疗和控制依赖于数量很少的驱虫药物，并且针对这些药物的耐药性可以迅速发展。寄生虫的神经肌肉系统，特别是离子通道和相关受体的兴奋和信号，已被证明是驱虫剂的突出目标。本文综述了寄生虫体内不同的离子通道，重点介绍了它们的独特特性和药理学敏感性。它还将简要回顾文献蠕虫多药外排，可能会调节寄生虫对驱虫药的敏感性，并可能证明新的或重新利用的药物，可以提高寄生虫的药物敏感性，也许克服耐药性有用的目标。
Infections with parasitic helminths such as schistosomes and soil-transmitted nematodes are hugely prevalent and responsible for a major portion of the global health and economic burdens associated with neglected tropical diseases. In addition, many of these parasites infect livestock and plants used in agriculture, resulting in further impoverishment. Treatment and control of these pathogens rely on anthelmintic drugs, which are few in number, and against which drug resistance can develop rapidly. The neuromuscular system of the parasite, and in particular, the ion channels and associated receptors underlying excitation and signaling, have proven to be outstanding targets for anthelmintics. This review will survey the different ion channels found in helminths, focusing on their unique characteristics and pharmacological sensitivities. It will also briefly review the literature on helminth multidrug efflux that may modulate parasite susceptibility to anthelmintics and may prove useful targets for new or repurposed agents that can enhance parasite drug susceptibility and perhaps overcome drug resistance.