Enhancement of place and object recognition memory in young adult and old rats by RS 67333, a partial agonist of 5-HT4 receptors
Enhancement of place and object recognition memory in young adult and old rats by RS 67333, a partial agonist of 5-HT4 receptors
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DOI：
10.1016/s0028-3908(01)00123-x
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发表时间：
2001-12-01
影响因子：
4.7
通讯作者：
Simon, H
中科院分区：
文献类型：
--
作者：
Lamirault, L;Simon, H
最近有证据表明，中枢 5-羟色胺 (5-HT)(4) 受体的激活可增强学习和记忆等认知过程。在本研究中，我们评估了选择性 5-HT4 受体激动剂 RS 67333 [1(4-氨基-5-氯-2-甲氧基苯基)-3-(1-正丁基-4-哌啶基)-1-丙酮]在旨在测试地点或物体识别记忆的两次试验识别任务中的效果。RS 67333 被注射到年轻人中（0.0001, 0.01, 1 mg/kg, i.p.) 和老年 (0.0001, 0.01, 1, 10 mg/kg, i.p.) 大鼠在采集阶段之前、之后立即或检索阶段之前注射, 以确定受化合物影响的信息处理阶段。在采集阶段之前注射时, RS 67333 (1 mg/kg) 增强了年轻成年大鼠的位置和物体识别能力。在老年大鼠中，在采集阶段之前注射 RS 67333 (10 mg/kg) 可以改善位置识别，在采集之前或信息处理巩固阶段注射时可以改善物体识别。 RS 67333 的有益作用因先前使用选择性 5-HT4 受体拮抗剂 GR 125487 [(1-[12-[甲基磺酰基)氨基]乙基]-4-哌啶基-甲基 5-氟-2-甲氧基-1H-吲哚-3-羧酸酯)的治疗而被消除； 10 mg/kg，腹膜内注射]。这些结果支持这样的观点，即选择性 5-HT4 受体激动剂可能在治疗与正常衰老或神经退行性疾病（例如阿尔茨海默氏病）相关的认知障碍中有价值。 (C) 2001 年，爱思唯尔科学有限公司出版。
There is recent evidence that activation of central 5-hydroxytryptamine (5-HT)(4) receptors enhances cognitive processes such as learning and memory. In the present study, we assessed the effects or a selective 5-HT4 receptors agonist, RS 67333 [1(4-amino-5-chloro-2-methoxyphenyl)-3-(1-n-butyl-4-piperidinyl)-1-propanone], in a two-trial recognition task designed to test place or object recognition memory.RS 67333 was injected in young adult (0.0001, 0.01, 1 mg/kg, i.p.) and old (0.0001, 0.01, 1, 10 mg/kg, i.p.) rats before the acquisition phase, immediately after it, or before the retrieval phase, to determine the stage of information processing affected by the compound.When injected before the acquisition phase, RS 67333 (1 mg/kg) enhanced place and object recognition in young adult rats. In old rats, RS 67333 (10 mg/kg) improved place recognition when injected before the acquisition phase, and object recognition when injected before the acquisition or in the consolidation phase of information processing. The beneficial effects of RS 67333 were abolished by prior treatment with a selective 5-HT4 receptors antagonist, GR 125487 [(1-[12-[methyl sulphonyl) amino]ethyl]-4-piperidinyl-methyl 5-fluoro-2-methoxy-1H-indole-3-carboxylate); 10 mg/kg, i.p.].These results support the view that selective 5-HT4 receptors agonists may be of value in the treatment of cognitive disorders related to normal aging or neurodegenerative conditions such as Alzheimer's disease. (C) 2001 Published by Elsevier Science Ltd.