Skin Substitutes and Wound Healing
Skin Substitutes and Wound Healing
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DOI：
10.1159/000178868
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发表时间：
2009-01-01
影响因子：
2.7
通讯作者：
Germain, L.
中科院分区：
文献类型：
--
作者：
Auger, F. A.;Lacroix, D.;Germain, L.
医学大大改进了临床上可用于治疗伤口的手段和方法。各种皮肤替代物的生产和使用大大提高了严重烧伤患者的存活率，但它们也显示出在许多其他应用方面的希望，包括涉及不危及生命的慢性伤口的病例。如今，已有20多种产品投入商业使用，更多的产品正在进行临床试验，世界各地的各个研究实验室正在研究大量的新型号。目前的许多产品都不包含任何活细胞，它们利用身体天生的自我愈合能力的能力各不相同。其他包括同种异体或自体来源的活细胞，通常被称为“细胞疗法”或“组织工程”产品。目前正在研究旨在通过使用重组生长因子和诸如微血管形成等附加特征来提高这些产品的愈合潜力的修饰和改进。对伤口愈合和无疤痕再生的基础研究带来了希望，即在伤口愈合后，我们最终将能够几乎完全恢复皮肤的外观和功能。版权所有(C)2009 S.Karger AG，巴塞尔
Medical science has vastly improved on the means and methods available for the treatment of wounds in the clinic. The production and use of various types of skin substitutes has led to dramatic improvements in the odds of survival for severely burned patients, but they have also shown promise for many other applications, including cases involving chronic wounds that are not life threatening. Nowadays, more than 20 products are commercially available, more are undergoing clinical trials and a large number of new models are being investigated in various research laboratories worldwide. Many of the current products do not contain any living cells and vary in their capacity to harness the innate capacity of the body to heal itself. Others include living cells, of allogeneic or autologous origin, and are often referred to as 'cellular therapy' or 'tissue-engineered' products. Modifications and improvements are currently investigated that aim at improving the healing potential of those products through the use of recombinant growth factors and additional features such as microvascularization. Fundamental research into wound healing and scar-free regeneration raises the hope that we will eventually be able to restore almost completely the appearance and function of skin after the healing of wounds. Copyright (C) 2009 S. Karger AG, Basel