Stressing Out over tRNA Cleavage
Stressing Out over tRNA Cleavage
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DOI：
10.1016/j.cell.2009.07.001
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发表时间：
2009-07-23
期刊：
影响因子：
64.5
通讯作者：
Parker, Roy
中科院分区：
文献类型：
--
作者：
Thompson, Debrah M.;Parker, Roy
对应激的保守反应涉及通常分泌或隔离的核糖核酸酶对细胞质转移 RNA (tRNA) 的核酸内切切割。核糖核酸酶激活或释放是细胞应激反应的一个有趣的新方面，对翻译、细胞凋亡、癌症和疾病进展具有潜在影响。
A conserved response to stress involves endonucleolytic cleavage of cytoplasmic transfer RNAs (tRNAs) by ribonucleases that are normally secreted or sequestered. Ribonuclease activation or release is an intriguing new aspect of cellular stress responses, with a potential impact on translation, apoptosis, cancer, and disease progression.