Osteoconductive HAp and TiO 2 Coatings on Titanium using Hydro-process
Osteoconductive HAp and TiO 2 Coatings on Titanium using Hydro-process
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使用氢工艺在钛上形成骨传导 HAp 和 TiO 2 涂层
DOI：
10.1557/proc-1236-ss08-23
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发表时间：
2009
期刊：
影响因子：
--
通讯作者：
M. Okido
中科院分区：
文献类型：
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作者：
D. Yamamoto;K. Kuroda;R. Ichino;M. Okido
羟基磷灰石(Ca 10 （po4) 6 (OH) 2, HAp）和二氧化钛（TiO 2，二氧化钛）由于其表现出的骨导电性而被用于骨界面植入物的应用。采用氢化工艺将其涂覆在钛种植体上，并对其体内性能进行了研究。在含有0.3 mM Ca(h2po4) 2和0.7 mM cacl2的水溶液中，采用热衬底法在cp-钛板或棒上形成HAp涂层。在形成碳酸盐磷灰石涂层时，在溶液中加入cahco3，在HAp/明胶和HAp/胶原复合涂层中加入酸溶性胶原（I型）。包覆实验在313 ~ 433 K、pH = 8条件下进行15 min或30 min。在2so4、h3po4和NaOH水溶液中，在298 K下阳极氧化，在钛植入物表面形成钛膜。采用XRD、EDX、FT-IR和SEM对包覆样品的性能进行了研究。并测量了氧化钛涂层的表面粗糙度。在体内评价中，将包膜棒标本植入大鼠股骨2周，观察其骨传导情况。植入两周后，在松质骨和皮质骨的涂层钛棒和未涂层钛棒上分别形成新骨。用于评估新骨形成的骨-种植体接触比R B-I与钛种植体上形成的化合物以及涂层工艺有很大关系。
Hydroxyapatite (Ca 10 (PO 4 ) 6 (OH) 2 , HAp) and titanium dioxide (TiO 2 , titania) are of interest for bone-interfacing implant applications, because of their demonstrated osteoconductive properties. They were coated on the titanium implants using hydro-processes and investigated the in vivo performance. HAp coatings were formed on cp-titanium plates or rods by the thermal substrate method in an aqueous solution included 0.3 mM Ca(H 2 PO 4 ) 2 and 0.7 mM CaCl 2 . In the formation of carbonate apatite coating, CaHCO 3 was added to the solution, and in HAp/gelatin and HAp/collagen composite coatings, acid-soluble collagen (Type I) was added. The coating experiments were conducted at 313-433 K and pH = 8 for 15 or 30 min. Titania films were formed on the titanium implants by anodizing at 2 SO 4 , H 3 PO 4 , and NaOH aqueous solutions at 298 K. The properties for the coated samples were studied using XRD, EDX, FT-IR, and SEM. And the surface roughness of titania coatings was measured. In in vivo evaluations, the coated rod specimens were implanted in rats femoral for 2 weeks, the osteoconduction on them was evaluated. Two weeks postimplantation, new bone formed on the coated and non-coated titanium rods in the cancellous bone and cortical bone, respectively. Bone-implant contact ratio, R B-I , which was used for the evaluation of new bone formation, was significantly depended on the compound formed on titanium implants, and also the coating processes.