Bioactive Ti metal analogous to human cancellous bone: Fabrication by selective laser melting and chemical treatments
Bioactive Ti metal analogous to human cancellous bone: Fabrication by selective laser melting and chemical treatments
复制标题
类似于人类松质骨的生物活性钛金属：通过选择性激光熔化和化学处理制造
DOI：
10.1016/j.actbio.2010.09.034
复制
发表时间：
2011-03-01
影响因子：
9.7
通讯作者：
Kokubo, T.
中科院分区：
文献类型：
--
作者：
Pattanayak, Deepak K.;Fukuda, A.;Kokubo, T.
选择性激光熔化(SLM)是一种直接从钛(Ti)粉末中制备具有复杂内部结构的三维多孔体的有用技术，不需要任何中间加工步骤，产品有望用作骨替代材料。在这项研究中，研究了获得致密产品所需的SLM工艺条件，如激光功率、扫描速度和孵化图案，使用粒径小于45微米的钛粉。结果表明，当激光功率与扫描速度之比大于0.5时，当开口间距小于激光直径时，可获得厚度小于1.8 mm的全致密板材，粉末层厚度为30µm。制备了具有类似人松质骨结构的多孔钛金属，并测量了其抗压强度。当孔隙率在75~55%时，抗压强度在35~120 Mpa之间。对SLM法制备的多孔钛金属进行了1300℃、Ar气氛下1h的热处理，以获得光滑的表面。将制备的样品用氢氧化钠处理。HCl，以及提供生物活性的热处理。场发射扫描电子显微镜显示，在多孔体的整个表面形成了细小的氧化钛网络。这些处理过的多孔体在3天内在模拟体液中的表面形成了骨状磷灰石。体内研究表明，日本大白兔股骨植入后12周内，新骨穿透毛孔，直接与骨壁粘连。化学处理和热处理的多孔体的骨亲和力指数明显高于未处理的种植体。(C)2010年Acta Materialia Inc.由爱思唯尔有限公司出版。版权所有。
Selective laser melting (SLM) is a useful technique for preparing three-dimensional porous bodies with complicated internal structures directly from titanium (Ti) powders without any intermediate processing steps, with the products being expected to be useful as a bone substitute. In this study the necessary SLM processing conditions to obtain a dense product, such as the laser power, scanning speed, and hatching pattern, were investigated using a Ti powder of less than 45 mu m particle size. The results show that a fully dense plate thinner than 1.8 mm was obtained when the laser power to scanning speed ratio was greater than 0.5 and the hatch spacing was less than the laser diameter, with a 30 mu m thick powder layer. Porous Ti metals with structures analogous to human cancellous bone were fabricated and the compressive strength measured. The compressive strength was in the range 35-120 MPa when the porosity was in the range 75-55%. Porous Ti metals fabricated by SLM were heat-treated at 1300 degrees C for 1 h in an argon gas atmosphere to smooth the surface. Such prepared specimens were subjected to NaOH. HCl, and heat treatment to provide bioactivity. Field emission scanning electron micrographs showed that fine networks of titanium oxide were formed over the whole surface of the porous body. These treated porous bodies formed bone-like apatite on their surfaces in a simulated body fluid within 3 days. In vivo studies showed that new bone penetrated into the pores and directly bonded to the walls within 12 weeks after implantation into the femur of Japanese white rabbits. The percentage bone affinity indices of the chemical- and heat-treated porous bodies were significantly higher than that of untreated implants. (C) 2010 Acta Materialia Inc. Published by Elsevier Ltd. All rights reserved.