Polycystic ovary syndrome in patients with focal epilepsy:: a study in 93 women
Polycystic ovary syndrome in patients with focal epilepsy:: a study in 93 women
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DOI：
10.1016/s0920-1211(00)00139-x
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发表时间：
2000-09-01
影响因子：
2.2
通讯作者：
Elger, CE
中科院分区：
文献类型：
--
作者：
Bauer, J;Jarre, A;Elger, CE
对绝经前局灶性癫痫妇女进行前瞻性队列分析，以确定多囊卵巢综合征（PCOS）是否是抗癫痫药物（AED）治疗妇女的常见结果。本研究在波恩大学癫痫科连续接受治疗的150例慢性局灶性癫痫女性患者中的93例（年龄在20 - 53岁之间;平均年龄34.3岁）中进行：38例接受一种AED（18例丙戊酸盐，20例卡马西平），36例接受一种以上药物，19例未接受药物治疗。随访6个月。PCOS定义为高雄激素血症（睾酮浓度> 0.7 ng/ml）合并月经过少（月经周期>35天）或闭经。PCOS在19例未接受药物治疗的患者中有2例（10.5%）被确定;在38例接受单药治疗的患者中有4例（10.5%）被确定，在接受一种以上AED治疗的患者中没有一例被确定。丙戊酸盐单药治疗患者的PCOS发生率（11.1%）与卡马西平治疗患者（10%）相似，也与未接受AED治疗的患者相似。本研究结果表明，局灶性癫痫女性患者的PCOS表现与丙戊酸盐或卡马西平给药无关。(C)2000 Elsevier Science B. V.保留所有权利。
A prospective cohort analysis of premenopausal women with focal epilepsy was conducted in order to determine whether polycystic ovary syndrome (PCOS) is a common finding in women treated with antiepileptic drugs (AED). This study was carried out in 93 of 150 women (aged between 20 and 53 years; mean, 34.3 years) with chronic focal epilepsy consecutively cared for at the Department of Epileptology, University of Bonn: 38 were receiving one AED (18 valproate, 20 carbamazepine), 36 more than one drug, and 19 were without medication. Patients were followed-up for 6 months. PCOS was defined as hyperandrogenism (testosterone concentration, > 0.7 ng/ml) combined with oligomenorrhoea (cycle length, >35 days) or amenorrhoea. PCOS was identified in two out of 19 (10.5%) patients receiving no medication; in four of 38 (10.5%) of patients receiving monotherapy, and in none of the patients receiving more than one AED. The incidence of PCOS in patients treated with valproate monotherapy (11.1%) was similar to that in patients treated with carbamazepine (10%) and also to that in patients not treated with AEDs. The results of this study suggest that the manifestation of PCOS in women with focal epilepsy is not related to the administration of valproate or carbamazepine. (C) 2000 Elsevier Science B.V. All rights reserved.