ESTIMATING RISKS OF PROGRESSING TO AIDS WHEN COVARIATES ARE MEASURED WITH ERROR
ESTIMATING RISKS OF PROGRESSING TO AIDS WHEN COVARIATES ARE MEASURED WITH ERROR
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DOI：
10.2307/2983065
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发表时间：
1993-01-01
影响因子：
2
通讯作者：
FAREWELL, VT
中科院分区：
文献类型：
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作者：
RABOUD, J;REID, N;FAREWELL, VT
一段时间以来，人们一直对量化感染人类免疫缺陷病毒（HIV）与免疫标志物变化相关的进展为艾滋病的风险感兴趣。直到最近，很少有人注意到这些标记物的相当大的可变性以及对相对风险估计的相应影响。我们估计了一组感染艾滋病毒的男同性恋者中与免疫标志物相关的艾滋病进展风险，这些人每季度随访5年。在标记的测量误差显示偏差这些估计。平滑技术在减少标记的变化量和随后的系数偏差方面的有效性进行了比较。仿真研究比较了各种平滑方法在减小估计系数偏差方面的有效性。
For some time, there has been interest in quantifying the risks of progressing to Aids from infection with the human immunodeficiency virus (HIV) associated with changes in the immunological markers. Until recently, little attention has been paid to the considerable variability of these markers and the corresponding effect on estimates of relative risk. We estimate the risks of progression to Aids associated with immunological markers among a group of homosexual men infected with HIV who have been followed at quarterly intervals for 5 years. Errors in measurement in the markers are shown to bias these estimates. Smoothing techniques are compared for their effectiveness in reducing the amount of variation in the markers and the subsequent bias in the coefficients. A simulation study compares the effectiveness of various methods of smoothing in reducing the bias of the estimated coefficient.