Reproducibility of MRI-determined proton density fat fraction across two different MR scanner platforms.
Reproducibility of MRI-determined proton density fat fraction across two different MR scanner platforms.
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DOI：
10.1002/jmri.22701
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发表时间：
2011-10
期刊：
影响因子：
--
通讯作者：
Sirlin CB
中科院分区：
文献类型：
--
作者：
Kang GH;Cruite I;Shiehmorteza M;Wolfson T;Gamst AC;Hamilton G;Bydder M;Middleton MS;Sirlin CB
评估两个 MR 扫描仪平台上磁共振成像 (MRI) 确定的质子密度脂肪分数 (PDFF) 的再现性，并使用磁共振波谱 (MRS) 确定的 PDFF 作为参考标准，以确认 MRI 确定的 PDFF 估计的准确性。这项前瞻性、横断面、交叉、观察性试点研究得到了机构审查委员会的批准。 21 名受试者签署了书面知情同意书，并在 1.5T（西门子 Symphony 扫描仪）和 3T（GE Signa Excite HD 扫描仪）上接受了肝脏 MRI 和 MRS。 MRI 确定的 PDFF 是使用轴向 2D 破坏梯度回忆回波序列进行估计的，该回波序列具有低翻转角以最小化 T1 偏差和六个回波时间以允许校正 T2* 和脂肪-水信号干扰效应。 MRS 确定的 PDFF 是使用受激回波采集模式序列进行估计的，该序列具有长重复时间以最小化 T1 偏差和五个回波时间以允许 T2 校正。通过相关分析评估 MRI 确定的 PDFF 的扫描仪间再现性；使用 MRS 确定的 PDFF 作为参考标准，通过线性回归分析分别评估每个场强的准确性。 1.5T 和 3T MRI 确定的 PDFF 估计值高度相关 (r = 0.992)。与 MRS 确定的 PDFF 参考相比，MRI 确定的 PDFF 估计在 1.5T（回归斜率/截距 = 0.958/−0.48）和 3T（斜率/截距 = 1.020/0.925）下都是准确的。 MRI 确定的 PDFF 估计是可重复的，并且使用 MRS 确定的 PDFF 作为参考标准，在 1.5T 和 3T 的两个 MR 扫描仪平台上准确。
To evaluate magnetic resonance imaging (MRI)-determined proton density fat fraction (PDFF) reproducibility across two MR scanner platforms and, using MR spectroscopy (MRS)-determined PDFF as reference standard, to confirm MRI-determined PDFF estimation accuracy. This prospective, cross-sectional, crossover, observational pilot study was approved by an Institutional Review Board. Twenty-one subjects gave written informed consent and underwent liver MRI and MRS at both 1.5T (Siemens Symphony scanner) and 3T (GE Signa Excite HD scanner). MRI-determined PDFF was estimated using an axial 2D spoiled gradient-recalled echo sequence with low flip-angle to minimize T1 bias and six echo-times to permit correction of T2* and fat-water signal interference effects. MRS-determined PDFF was estimated using a stimulated-echo acquisition mode sequence with long repetition time to minimize T1 bias and five echo times to permit T2 correction. Interscanner reproducibility of MRI determined PDFF was assessed by correlation analysis; accuracy was assessed separately at each field strength by linear regression analysis using MRS-determined PDFF as reference standard. 1.5T and 3T MRI-determined PDFF estimates were highly correlated (r = 0.992). MRI-determined PDFF estimates were accurate at both 1.5T (regression slope/intercept = 0.958/−0.48) and 3T (slope/intercept = 1.020/0.925) against the MRS-determined PDFF reference. MRI-determined PDFF estimation is reproducible and, using MRS-determined PDFF as reference standard, accurate across two MR scanner platforms at 1.5T and 3T.