Copper deficiency in sheep in Western Australia; a preliminary account of the aetiology of enzootic ataxia of lambs and an anaemia of ewes.
Copper deficiency in sheep in Western Australia; a preliminary account of the aetiology of enzootic ataxia of lambs and an anaemia of ewes.
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DOI：
10.1111/j.1751-0813.1937.tb04108.x
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发表时间：
1937-01-01
影响因子：
1.1
通讯作者：
Chapman, F. E.
中科院分区：
文献类型：
--
作者：
Bennetts, H. W.;Chapman, F. E.
这种疾病似乎与英格兰和南美的伦格拉病相同，最初被认为是铅中毒，通过提供含有商业氯化铵的舔物来删除怀孕母羊的努力似乎取得了令人振奋的结果。然而，随后，当使用纯氯化铵时，任何好处都得不到。对纯氯化铵和商品氯化铵以及患病和正常羔羊的肝脏进行的光谱分析表明，铜缺乏。本文描述了在调查这一可能性方面所做的工作和取得的结果。研究人员发现，事实上，与正常母羊相比，患病羔羊的肝脏以及患病母羊的血液和乳汁中铜的含量明显不足。给12只妊娠母羊服用15 mg。0.1%硫酸铜溶液形式的铜完全防止了其后代共济失调的发生，而22只对照母羊的后代全部受到影响。饲养在这个不健全国家的繁殖母羊会患上贫血，这种贫血对小剂量的铜也有很好的反应。奇怪的是，这是一种大细胞增多性贫血。用铜治疗的贫血母羊的身体状况和总体幸福感都得到了迅速的改善。目前正在调查受影响地区土壤和牧场的铜含量。这篇文章给出了所用方法的全部细节，并应在原文中参考。-D.这表明该病是由于牧场和土壤中铜的缺乏所致，但现有的化学分析结果不支持这一说法。澳大利亚羔羊共济失调是一种地方性疾病，与。在英国，羔羊的背部摇摆。早期的假设是，地方性共济失调是由铅中毒引起并受益于氯化铵，这一假设被推翻。对受影响的水坝及其羔羊的器官、血液和乳汁的分析显示，铜含量低于正常组织和乳汁。铜疗法治愈了母羊的贫血，并抑制了羔羊中枢神经系统病变的进一步发展。这些事实表明，发生这种疾病的牧场和土壤中存在铜缺乏，但现有的有限的化学分析结果并不支持这一观点。
This disease, which appears to be identical with so-called " sway-back " in England and renguera in South America, was first thought to be lead poisoning, and efforts to " delead " the pregnant ewes by providing licks containing commercial ammonium chloride appeared to give promising results. Subsequently, however, when pure ammonium chloride was used, no benefit whatever was derived. Spectrographic examinations of pure and commercial ammonium chloride and of livers from affected and normal lambs then suggested that there was a copper deficiency. The article describes the work undertaken and results obtained in investigating this possibility. It was found that there was, in fact, a very marked shortage of copper in the livers of affected lambs and in the blood and milk of affected ewes, when these were compared with normal ewes. The administration to 12 pregnant ewes of 15 mg. copper in the form of 0.1 % cupric sulfate solution completely prevented the occurrence of ataxia in their progeny, whereas all the progeny of 22 control ewes were affected. The breeding ewes retained on the unsound country develop an anaemia which also responds well to small doses of copper. Curiously enough this anaemia is of the macrocytic hyperchromic variety. The anaemic ewes treated with copper rapidly improved in bodily condition and in general well-being. The copper contents of soils and pastures in affected areas are being investigated. The article gives full details of the methods used and should be consulted in the original. -D. A. GILL.It is suggested that the disease was due to a Cu deficiency in pasture and soil, but this suggestion is not supported by the results of the chemical analysis available.Enzootic ataxia of lambs in Australia is a localized disease with close resemblance to. sway-back of lambs in Britain. The earlier hypothesis that enzootic ataxia was caused by lead poisoning and benefited by ammonium chloride is disproved. Analysis of organs, blood and milk from affected dams and their lambs showed a lower Cu content than in normal tissues and milk. Cu therapy cured anaemia in the ewes and inhibited further development of central nervous system lesions in the lambs. These facts suggest a Cu deficiency in pasture and soil in which the disease occurs, but the limited results of chemical analysis available do not support this view.-A. H. H. Fraser.