Effects of psyllium therapy on stool characteristics, colon transit and anorectal function in chronic idiopathic constipation
Effects of psyllium therapy on stool characteristics, colon transit and anorectal function in chronic idiopathic constipation
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DOI：
10.1111/j.1365-2036.1995.tb00433.x
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发表时间：
1995-12-01
影响因子：
7.6
通讯作者：
Quigley, EMM
中科院分区：
文献类型：
--
作者：
Ashraf, W;Park, F;Quigley, EMM
背景：洋车前子广泛用于便秘的对症治疗，其对结肠功能的影响及其与症状反应的相关性尚未确定。方法：在 4 周基线、安慰剂、磨合期后，22 名通过前瞻性大便日记确认的特发性便秘受试者被随机分配接受洋车前子（5 g b.d.，11 名患者）或安慰剂（11 名患者）治疗 8 周，然后再接受 4 周在每个研究阶段开始和结束时进行结肠传输研究和肛门直肠测压，受试者在日记中记录每日排便频率、排便困难和每周粪便重量。结果：在车前子治疗 8 周后，大便频率显着增加（3.8 +/- 0.4 与 2.9 +/- 0.1 次粪便/周，P < 0.05），粪便重量也增加（665.3 +/- 95.8 克与 405.2 +/- 75.9 克，P < 0.05）。受试者还报告了车前草的粪便稠度（粪便稠度评分：3.2 +/- 0.2 vs. 3.8 +/- 0.2，P < 0.05）和排便疼痛（疼痛评分：2.0 +/- 0.4 vs. 2.6. +/- 0.5，P < 0.05）的改善。车前子的结肠传输和肛门直肠测压参数没有变化。使用安慰剂治疗的受试者在便秘的主观或客观测量方面没有表现出任何变化。结论：洋车前子可增加特发性便秘的大便频率和重量，并改善大便稠度。这些影响与结肠或直肠运动功能的显着变化无关。我们认为车前子对便秘的有益作用主要与促进排便过程有关。
Background: Psyllium is widely used in the symptomatic therapy of constipation, Its effects on colonic function and their correlation with symptomatic response have not been defined.Methods: After a 4-week baseline, placebo, run-in phase, 22 subjects with idiopathic constipation confirmed by prospectively administered stool diaries were randomly assigned to receive either psyllium (5 g b.d., 11 patients) or placebo (11 patients) for 8 weeks, followed by another 4-week wash-out, placebo phase, A colon transit study and anorectal manometry were performed at the beginning and at the end of each study phase, Subjects recorded, in diaries, their daily stool frequency, difficulty with defecation and weekly stool weight.Results: Stool frequency increased significantly after 8 weeks of psyllium treatment (3.8 +/- 0.4 vs. 2.9 +/- 0.1 stools/week, P < 0.05) as did stool weight (665.3 +/- 95.8 g vs. 405.2 +/- 75.9 g, P < 0.05). Subjects also reported an improvement in stool consistency (stool consistency score: 3.2 +/- 0.2 vs. 3.8 +/- 0.2, P < 0.05) and pain on defecation (pain score: 2.0 +/- 0.4 vs. 2.6. +/- 0.5, P < 0.05) on psyllium. Colon transit and anorectal manometry parameters were unchanged on psyllium. Subjects treated with placebo did not show any change in either subjective or objective measures of constipation.Conclusions: Psyllium increases stool frequency and weight and improves stool consistency in idiopathic constipation. These effects are not associated with significant changes in either colonic or rectal motor function. We suggest that the beneficial effects of psyllium in constipation are primarily related to a facilitation of the defecatory process.