Photodynamic therapy with fullerenes
Photodynamic therapy with fullerenes
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DOI：
10.1039/b711141j
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发表时间：
2007-01-01
影响因子：
3.1
通讯作者：
Hamblin, Michael R.
中科院分区：
文献类型：
--
作者：
Mroz, Pawel;Tegos, George P.;Hamblin, Michael R.
富勒烯是一类完全由碳原子构成的封闭笼状纳米材料。大量的注意力已经集中在开发这些独特分子的医学用途上，特别是当它们用官能团衍生化以使它们可溶并因此能够与生物系统相互作用时。由于其扩展的π-共轭，它们吸收可见光，具有高的三重态产率，并且可以在照射时产生活性氧物质，这表明富勒烯在光动力疗法中的可能作用。根据分子中引入的官能团，富勒烯可以有效地光灭活病原微生物细胞和恶性癌细胞之一或两者。该机制似乎涉及超氧阴离子以及单线态氧，并且在适当的条件下，富勒烯可能比临床应用的光敏剂具有优势，用于介导某些疾病的光动力治疗。
Fullerenes are a class of closed- cage nanomaterials made exclusively from carbon atoms. A great deal of attention has been focused on developing medical uses of these unique molecules especially when they are derivatized with functional groups to make them soluble and therefore able to interact with biological systems. Due to their extended pi-conjugation they absorb visible light, have a high triplet yield and can generate reactive oxygen species upon illumination, suggesting a possible role of fullerenes in photodynamic therapy. Depending on the functional groups introduced into the molecule, fullerenes can effectively photoinactivate either or both pathogenic microbial cells and malignant cancer cells. The mechanism appears to involve superoxide anion as well as singlet oxygen, and under the right conditions fullerenes may have advantages over clinically applied photosensitizers for mediating photodynamic therapy of certain diseases.