Computational characterization of hemorheology in the lenticulostriate arteries predicts the location of vessel rupture during hypertensive intracerebral hemorrhage
Computational characterization of hemorheology in the lenticulostriate arteries predicts the location of vessel rupture during hypertensive intracerebral hemorrhage
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DOI：
10.1016/j.hest.2021.06.004
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发表时间：
2021-06
影响因子：
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通讯作者：
Zongkun Hou;Xiaofei Li;Peng Ren;Yuhua Gong;Tingwang Guo;Paul R. Krafft;Shilei Hao;Bochu Wang
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文献类型：
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作者：
Zongkun Hou;Xiaofei Li;Peng Ren;Yuhua Gong;Tingwang Guo;Paul R. Krafft;Shilei Hao;Bochu Wang
高血压脑出血(ICH)通常由供应豆纹动脉(LSA)的基底节和丘脑破裂引起。这项研究的目的是确定LSA内容易破裂的区域。为了确定血管破裂的位置，建立了LSA的二维数学模型，并使用平行板流室来评估剪应力对内皮细胞损伤的作用。在LSA内，易破裂的区域是供应基底神经节和丘脑的血管的远端部分，那些位于大脑中动脉(MCA)主干附近的区域，以及LSA分叉点的管壁。此外，在LSA的起始处观察到更严重的内皮细胞损伤。这项研究确定了LSA内血管破裂的易感部位，未来可用于预测和潜在地预防临床高血压脑出血的发生。
Hypertensive intracerebral hemorrhage (ICH) is commonly provoked by rupture of basal ganglia and thalamus supplying lenticulostriate arteries (LSAs). The purpose of this study was to identify regions within the LSAs that are prone to rupture. A two-dimensional mathematical model of the LSAs was created in order to identify the location of vascular rupture and a parallel-plate flow chamber was used to evaluate the role of shear stresses on endothelial cell damage. Areas within the LSAs that were prone to rupture were distal parts of the vessels supplying the basal ganglia and thalamus, those located in close proximity to the trunk of the middle cerebral artery (MCA), as well as the vessel wall at the bifurcation point of the LSAs. Furthermore, more severe endothelial cell damage was observed at the origin of the LSAs. This study identified susceptible sites of blood vessel rupture within the LSAs, which, in the future, could be used to anticipate and potentially prevent the occurrence of clinical hypertensive ICH.