Titin antibodies in patients with late onset myasthenia gravis: clinical correlations.
Titin antibodies in patients with late onset myasthenia gravis: clinical correlations.
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DOI：
10.3109/08916939509001933
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发表时间：
1995
期刊：
影响因子：
3.5
通讯作者：
G. Skeie;Å. Mygland;J. Aarli;N. Gilhus
中科院分区：
文献类型：
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作者：
G. Skeie;Å. Mygland;J. Aarli;N. Gilhus
我们对21名40岁以后发病的无胸腺瘤的去胸腺患者的血清进行了抗titin抗体的检测，使用了含有titin肽mtt -30的ELISA法。肌球蛋白是横纹肌特有的肌原纤维蛋白，对肌肉细胞的弹性反冲起重要作用。21份血清中有9份检测到Titin抗体。以6分残疾评分（0-5分）评估的MG症状在titin抗体阳性的患者中在疾病高峰期明显更严重；3.7 vs. 3.1 （p < 0.02）和最晚随访时间；2.1 vs 0.8 （p < 0.01）。所有titin抗体阳性的患者至少随访时均接受免疫抑制药物治疗，而12例没有titin抗体的患者中只有3例使用免疫抑制药物。迟发性非胸腺瘤MG患者中循环titin抗体的存在表明疾病更为严重。
We have tested sera from 21 thymectomized patients with onset of MG after 40 years of age and without thymoma for antibodies against titin, using ELISA with the titin peptide MGT-30. Titin is a myofibrillar protein unique to striated muscle and important for the elastic recoil of muscle cells. Titin antibodies were detected in 9 of the 21 sera. MG symptoms as assessed by a 6 point disability score (0-5) were significantly more severe in the titin antibody positive patients both at peak of illness; 3.7 vs. 3.1 (p < 0.02) and at latest follow up; 2.1 vs. 0.8 (p < 0.01). All titin antibody positive patients were on immunosuppressive drug treatment at least follow-up, whereas only 3 of 12 patients without titin antibodies used immunosuppressive drugs. The presence of circulating titin antibodies in late-onset non-thymoma MG patients indicates a more severe disease.