Polyketides isolated from endophyte Fusarium armeniacum and their cytotoxic activities
Polyketides isolated from endophyte Fusarium armeniacum and their cytotoxic activities
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DOI：
10.1016/j.phytol.2023.01.014
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发表时间：
2023-01-21
影响因子：
1.7
通讯作者：
Shiono，Yoshihito
中科院分区：
文献类型：
--
作者：
Sato，Shiho;Sofian，Ferry Ferdiansyah;Shiono，Yoshihito
除了结构上令人感兴趣的聚酮化合物外，还分离出了四种curvicollides E、F、G和H，并通过将其光谱数据与文献进行比较，沿着已知的curvicollides B和C进行了鉴定。对所有化合物进行了体外细胞毒活性研究，其中1个化合物表现出较强的细胞毒活性（IC 50为1.86 μg/mL）。
In addition to the structurally interesting polyketides, four curvicollides E, F, G, and H were isolated and identified via comparison of their spectroscopic data with the literature, along with known curvicollides B and C. All compounds were studied in vitro for their cytotoxic activity against the HeLa cervical cancer human ovarian carcinoma cell lines and1showed potent cytotoxic activity (IC501.86 μg/mL) among the isolated compounds.