Chromatin remodeling, histone modifications, and DNA methylation - How does it all fit together?
Chromatin remodeling, histone modifications, and DNA methylation - How does it all fit together?
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DOI：
10.1002/jcb.10286
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发表时间：
2002-01-01
影响因子：
4
通讯作者：
Robertson, KD
中科院分区：
文献类型：
--
作者：
Geiman, TM;Robertson, KD
DNA甲基化在基因转录和染色质结构的控制中是重要的。这个过程的复杂性才刚刚开始阐明与其他表观遗传机制的关系。在组蛋白甲基化和染色质重塑领域令人兴奋的新研究清楚地表明，这些不同机制和DNA甲基化之间的联系对于控制染色体结构和基因表达是多么重要。新出现的证据表明，染色质重塑酶和组蛋白甲基化是必要的适当的DNA甲基化模式。其他组蛋白修饰，如乙酰化和磷酸化，反过来又影响组蛋白甲基化，组蛋白甲基化似乎也高度依赖于染色质重塑酶。这篇评论将总结什么是可能只是一个新的信息，最终将链接所有哺乳动物基因组的表观遗传修饰洪水的开始。还将提出一个模型来解释染色质修饰如何导致基因组DNA甲基化模式。
DNA methylation is important in the control of gene transcription and chromatin structure. The complexities of this process are just beginning to be elucidated in relationship to other epigenetic mechanisms. Exciting new research in the areas of histone methylation and chromatin remodeling make it clear just how important the connections between these various mechanisms and DNA methylation are for the control of chromosome structure and gene expression. Emerging evidence suggests that chromatin remodeling enzymes and histone methylation are essential for proper DNA methylation patterns. Other histone modifications, such as acetylation and phosphorylation, in turn, affect histone methylation and histone methylation also appears to be highly reliant on chromatin remodeling enzymes. This review will summarize what is likely only the beginning of a flood of new information that will ultimately link all epigenetic modifications of the mammalian genome. A model will also be put forth to account for how chromatin modifications lead to genomic DNA methylation patterns.