Norine: update of the nonribosomal peptide resource
Norine: update of the nonribosomal peptide resource
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DOI：
10.1093/nar/gkz1000
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发表时间：
2020-01-08
影响因子：
14.9
通讯作者：
Pupin, Maude
中科院分区：
文献类型：
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作者：
Flissi, Areski;Ricart, Emma;Pupin, Maude
Norine是专门用于非核糖体肽（nrp）的独特资源，现在更新了一个新的管道，以自动化大规模采购和增强注释。挖掘外部数据库以提取尚未在Norine中使用的nrp。为了保持高数据质量，应用连续的过滤器来自动验证NRP注释，并且只有经过验证的数据才会插入到数据库中。外部数据库也用于完成Norine中已有NRPs的注释。此外，Norine内部和Norine与外部源之间的注释一致性也报告了注释错误。有些可以自动纠正，有些则需要人工管理。这种新方法导致了539个新的nrp的插入，并增加或纠正了几乎所有Norine条目的注释。同时还集成了两种新的分析NRP （rBAN）化学结构和从NRP的质荷比推断分子式的工具（Kendrick formula Predictor）。
Norine, the unique resource dedicated to nonribosomal peptides (NRPs), is now updated with a new pipeline to automate massive sourcing and enhance annotation. External databases are mined to extract NRPs that are not yet in Norine. To maintain a high data quality, successive filters are applied to automatically validate the NRP annotations and only validated data is inserted in the database. External databases were also used to complete annotations of NRPs already in Norine. Besides, annotation consistency inside Norine and between Norine and external sources have reported annotation errors. Some can be corrected automatically, while others need manual curation. This new approach led to the insertion of 539 new NRPs and the addition or correction of annotations of nearly all Norine entries. Two new tools to analyse the chemical structures of NRPs (rBAN) and to infer a molecular formula from the mass-to-charge ratio of an NRP (Kendrick Formula Predictor) were also integrated.