Association of ABO blood groups with glaucoma in the Pakistani population
Association of ABO blood groups with glaucoma in the Pakistani population
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DOI：
10.3129/i09-104
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发表时间：
2009-10-01
影响因子：
4.2
通讯作者：
Qamar, Raheel
中科院分区：
文献类型：
--
作者：
Khan, Muhammad Imran;Micheal, Shazia;Qamar, Raheel
目的：研究巴基斯坦人群中血型与不同类型青光眼的关系，包括原发性开角型青光眼 (POAG)、原发性闭角型青光眼 (PCAG) 和假性剥脱性青光眼 (PEXG)。研究设计：本研究是一项前瞻性病例对照研究。参与者：对 2046 名对照者和 477 名青光眼患者（220 名 POAG、220 名青光眼患者）中的 ABO 和 Rh 血型进行了分析。 146 PCAG 和 I I I PEXG)。方法：使用血凝模式确定所有受试者中 ABO 和 Rh 血型的流行率。采用Logistic回归分析来评估不同血型与青光眼之间的关联。结果：在本研究中，患者中A、B、AB和0型血的比例分别为19%、41%、10%和30%，而在对照组中，该值分别为26%、31%、12%和31%。 B 血型与青光眼之间存在显着的正相关性（p 值 < 0.05，比值比 [OR] 1.5，chi(2) 15.8）。 Logistic 回归分析显示，B 型血与所有类型的青光眼相关，POAG 的 OR 为 1.35 (95% CI 1.01-1.80；p = 0.04)，PCAG 的 OR 为 1.71 (95% CI 1.21-2.40；p = 0.002)，PCAG 的 OR 为 1.61 (95% CI 1.09-2.36；p = 0.04)。 0.016) 对于 PEXG。与对照组相比，POAG 还被发现与 Rh 等位基因相关 (p < 0.05)，OR 为 4.05 (95% Cl 2.98-5.51)。结论：在巴基斯坦患者队列中，B 型血与所有类型的青光眼相关，而 Rh 等位基因仅与 POAG 相关。
Objective: To study the association of blood groups with different types of glaucoma including primary open-angle glaucoma (POAG), primary closed-angle glaucoma (PCAG), and pseudoexfoliative glaucoma (PEXG) in the Pakistani population.Study Design: The present study was a prospective case control study.Participants: ABO and Rh blood groups were analyzed in 2046 controls and 477 glaucoma patients (220 POAG, 146 PCAG, and I I I PEXG).Methods: Hemagglutination patterns were used to determine the prevalence of the ABO and Rh blood groups in all the subjects. Logistic regression analysis was carried out to evaluate any association of the different blood groups with glaucoma.Results: In the present study, the percentage of blood groups A, B,AB, and 0 in patients was found to be 19%, 41%, 10%, and 30%, and in the control group, the values were 26%, 31%, 12%, and 31%, respectively. A significant positive association was found between the B blood group and glaucoma (p value < 0.05, odds ratio [OR] 1.5, and chi(2) 15.8). Logistic regression analysis revealed that the blood group B was associated with all types of glaucoma with OR of 1.35 (95% CI 1.01-1.80; p = 0.04) for POAG, 1.71 (95% Cl 1.21-2.40; p = 0.002) for PCAG, and 1.61 (95% Cl 1.09-2.36; p = 0.016) for PEXG. POAG was also found to be associated with the Rh-allele (p < 0.05) with an OR of 4.05 (95% Cl 2.98-5.51), as compared with controls.Conclusions: In the Pakistani patient cohort, blood group B is associated with all types of glaucoma and the Rh-allele is associated only with POAG.