Determinants of long-term survival in a population-based cohort study of patients with head and neck cancer from Scotland
Determinants of long-term survival in a population-based cohort study of patients with head and neck cancer from Scotland
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DOI：
10.1002/hed.25630
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发表时间：
2019-06-01
影响因子：
2.9
通讯作者：
MacKenzie, Kenneth
中科院分区：
文献类型：
--
作者：
Ingarfield, Kate;McMahon, Alex D.;MacKenzie, Kenneth
背景：我们采用不同的生存方式对头颈癌的长期生存率进行了研究。方法从苏格兰头颈癌审计中心对患者进行随访。采用Kaplan-Meier方法计算总存活率和疾病特异性存活率。净存活率按Pohar-Perme法计算。使用相互调整的COX比例风险模型来确定生存的预测因素。结果共1820例患者进入分析。总的12年生存率为26.3%(24.3%，28.3%)。12年的疾病特异性生存率为56.9%(54.3%，59.4%)。12年净生存率为41.4%(37.6%，45.1%)。结论与长期生存相关的影响因素包括年龄、分期、治疗方式、WHO工作状态、饮酒、吸烟行为和解剖部位。我们建议将净存活率用于HNC患者的长期结果--它排除了其他死因，这些死因在总体存活率中被高估，而在特定疾病的存活率中被低估。
Background We investigated long-term survival from head and neck cancer (HNC) using different survival approaches. Methods Patients were followed-up from the Scottish Audit of Head and Neck Cancer. Overall survival and disease-specific survival were calculated using the Kaplan-Meier method. Net survival was calculated by the Pohar-Perme method. Mutually adjusted Cox proportional hazards models were used to determine the predictors of survival. Results A total of 1820 patients were included in the analyses. Overall survival at 12 years was 26.3% (24.3%, 28.3%). Disease-specific survival at 12 years was 56.9% (54.3%, 59.4%). Net survival at 12 years was 41.4% (37.6%, 45.1%). Conclusion Determinants associated with long-term survival included age, stage, treatment modality, WHO performance status, alcohol consumption, smoking behavior, and anatomical site. We recommend that net survival is used for long-term outcomes for HNC patients-it disentangles other causes of death, which are overestimated in overall survival and underestimated in disease-specific survival.