Genetic screening for signal transduction in the era of network biology
Genetic screening for signal transduction in the era of network biology
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DOI：
10.1016/j.cell.2007.01.007
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发表时间：
2007-01-26
期刊：
影响因子：
64.5
通讯作者：
Perrimon, Norbert
中科院分区：
文献类型：
--
作者：
Friedman, Adam;Perrimon, Norbert
与基于动物的突变体表型测定相反，最近的生物化学和定量遗传学研究已经确定了已知信号传导途径的数百种潜在调节剂。我们讨论了以前的模型和新数据之间的差异，提出了一个不同的信号概念框架，结合时间依赖性的定量贡献，并建议这个新的框架可以如何影响我们的研究人类疾病。
In contrast to animal-based mutant phenotype assays, recent biochemical and quantitative genetic studies have identified hundreds of potential regulators of known signaling pathways. We discuss the discrepancy between previous models and new data, put forward a different signaling conceptual framework incorporating time-dependent quantitative contributions, and suggest how this new framework can impact our study of human disease.