Tumor microenviroment and hepatocellular carcinoma metastasis
Tumor microenviroment and hepatocellular carcinoma metastasis
复制标题
DOI：
10.1111/jgh.12091
复制
发表时间：
2013-08-01
影响因子：
4.1
通讯作者：
Chen, Lei
中科院分区：
文献类型：
--
作者：
Wang, Hongyang;Chen, Lei
近几十年来，肿瘤细胞与周围瘤周基质之间的串扰作为一个涉及肝癌发生、肿瘤侵袭和转移过程的动态系统得到了广泛研究。除肝细胞外，肝肿瘤微环境一般分为细胞和非细胞成分，包括肝星状细胞、成纤维细胞、免疫细胞、内皮细胞、间充质干细胞，以及生长因子、细胞因子、细胞外基质、激素和病毒等。非细胞成分通过促进上皮-间充质转化，由于肝细胞癌患者死亡的主要原因是肿瘤进展和转移，因此更好地了解肿瘤转移过程中肝细胞与其环境之间的相互作用可能有助于发现新的分子靶点。
The cross talk between tumor cells and the surrounding peritumoral stroma has been extensively studied as a dynamic system involving the processes of hepatocarcinogenesis, tumor invasion, and metastasis in recent few decades. Besides hepatocytes, liver tumor microenvironments are generally classified into cellular and noncellular components, including hepatic stellate cells, fibroblasts, immune, endothelial, mesenchymal stem cells, together with growth factors, cytokines, extracellular matrix, hormone as well as viruses et al. The noncellular components manipulate hepatocellular carcinoma invasion and metastasis by facilitating epithelial-mesenchymal transition, increasing proteolytic activity of matrix metalloproteinases, and regulating antitumor immunity, etc. Because the main cause of death in hepatocellular carcinoma patients is tumor progression with metastasis, a better understanding of the interplay between hepatocytes and their environment during tumor metastasis may be helpful for the discovery of novel molecular targets.