THE GENOME : Joining , Resolving , and Separating Sister Chromatids During Mitosis and Meiosis
THE GENOME : Joining , Resolving , and Separating Sister Chromatids During Mitosis and Meiosis
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发表时间：
2006
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通讯作者：
K. Nasmyth
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作者：
K. Nasmyth
摘要姐妹染色单体在分裂中期到分裂后期的分离是所有细胞中最引人注目的事件之一，也是所有有性生殖和无性生殖的一个重要方面。直到最近，这一过程的分子基础仍然不清楚。新的研究已经确定了在中期板上对齐时将姐妹篇保持在一起的蛋白质。它还揭示了在有丝分裂和减数分裂过程中溶解姐妹染色单体凝聚力的机制。这些发现有望为了解癌细胞中发生的染色体分离缺陷以及减数分裂过程中非整倍体产生的病理途径提供见解。
■ Abstract The separation of sister chromatids at the metaphase to anaphase transition is one of the most dramatic of all cellular events and is a crucial aspect of all sexual and asexual reproduction. The molecular basis for this process has until recently remained obscure. New research has identified proteins that hold sisters together while they are aligned on the metaphase plate. It has also shed insight into the mechanisms that dissolve sister chromatid cohesion during both mitosis and meiosis. These findings promise to provide insights into defects in chromosome segregation that occur in cancer cells and into the pathological pathways by which aneuploidy arises during meiosis.