Blood and Liver Concentrations of Vitamins A and E in Children with Cystic Fibrosis of the Pancreas
Blood and Liver Concentrations of Vitamins A and E in Children with Cystic Fibrosis of the Pancreas
复制标题
胰腺囊性纤维化儿童血液和肝脏中维生素 A 和 E 的浓度
作者：
B. Underwood;C. Denning
胰腺囊性纤维化（CFP）患者血浆中维生素A水平的中位数（18 μg/100 ml）不到对照组（39 μg/100 ml）的一半，而肝脏中维生素A水平的中位数（57 μg/g）高出近3.5倍（表2）。患者血浆和肝脏中的维生素E浓度都低于对照组的三分之一。数据表明，补充了维生素A的CFP儿童无法维持正常的循环维生素A水平，因为从储存组织中动员或运输的缺陷，而不是因为组织消耗。然而，血液中维生素E水平低反映的是组织损耗，而不是运输缺陷。推测：CFP儿童从肝脏中动员或运输维生素A的能力明显缺陷的原因可能是由于合成运输蛋白的能力有限或肝视黄酰基酯水解酶活性降低。这些替代方案正在研究中。
Extract: The median vitamin A level in plasma of patients with cystic fibrosis of the pancreas (CFP) (18 μg/100 ml) was less than half that of a control group (39 μg/100 ml), whereas the median vitamin A level in liver (57 μg/g) was nearly 3.5 times higher (Table II.). Concentrations of vitamin E in both the plasma and the liver of the patients were less than one-third those of the control group. The data suggest that vitamin A-supplemented children with CFP are unable to maintain normal circulating levels of vitamin A because of a defect in mobilization or transport from storage tissue, rather than because of tissue depletion. Low blood levels of vitamin E, however, reflect tissue depletion and not defective transport.Speculation: The cause of the apparent defect in ability to mobilize or transport vitamin A from the liver in children with CFP may be due to a limited ability to synthesize transport proteins or to a reduced activity of hepatic retinyl ester hydrolase enzymes These alternatives are under investigation.