Higher Energy Expenditure in Humans Predicts Natural Mortality
Higher Energy Expenditure in Humans Predicts Natural Mortality
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DOI：
10.1210/jc.2010-2944
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发表时间：
2011-06-01
影响因子：
5.8
通讯作者：
Krakoff, Jonathan
中科院分区：
文献类型：
--
作者：
Jumpertz, Reiner;Hanson, Robert L.;Krakoff, Jonathan
内容：更高的代谢率增加自由基的形成，这可能会加速衰老，导致早期死亡。目的：我们的目的是确定是否较高的代谢率测量两种不同的方法预测早期自然死亡的人。设计：非糖尿病健康Pima印度志愿者（n = 652）作为肥胖和糖尿病危险因素纵向研究的一部分，被送入住院部约7天。研究参与者的生命状态确定至2006年12月31日。24小时能量消耗（24 EE）在508人中进行了测量，静息代谢率（RMR）在384人中进行了测量，240人在不同的日子进行了两次测量。在1985年至2006年期间，在呼吸室中收集了24 EE的数据，平均（SD）随访时间为11.1（6.5）年，在1982年至2006年期间，使用开路呼吸罩系统收集了RMR的数据，平均随访时间为15.4（6.3）年。考克斯回归模型被用来测试EE对自然死亡率的影响，控制年龄，性别和体重。EE每增加100千卡/24小时，自然死亡风险增加1.29（95%置信区间= 1.00-1.66; P < 0.05），24 EE组和1.25（95%可信区间= 1.01-1.55; P < 0.05），在比例风险分析中校正年龄、性别和体重后。24 EE或RMR反映的较高代谢率预测早期自然死亡率，表明较高的能量周转可能加速人类衰老。（临床内分泌代谢杂志96：E972-E976，2011）
Context: Higher metabolic rates increase free radical formation, which may accelerate aging and lead to early mortality.Objective: Our objective was to determine whether higher metabolic rates measured by two different methods predict early natural mortality in humans.Design: Nondiabetic healthy Pima Indian volunteers (n = 652) were admitted to an inpatient unit for approximately 7 d as part of a longitudinal study of obesity and diabetes risk factors. Vital status of study participants was determined through December 31, 2006. Twenty-four-hour energy expenditure (24EE) was measured in 508 individuals, resting metabolic rate (RMR) was measured in 384 individuals, and 240 underwent both measurements on separate days. Data for 24EE were collected in a respiratory chamber between 1985 and 2006 with a mean (SD) follow-up time of 11.1 (6.5) yr and for RMR using an open-circuit respiratory hood system between 1982 and 2006 with a mean follow-up time of 15.4 (6.3) yr. Cox regression models were used to test the effect of EE on natural mortality, controlled for age, sex, and body weight.Results: In both groups, 27 natural deaths occurred during the study period. For each 100-kcal/24 h increase in EE, the risk of natural mortality increased by 1.29 (95% confidence interval = 1.00-1.66; P < 0.05) in the 24EE group and by 1.25 (95% confidence interval = 1.01-1.55; P < 0.05) in the RMR group, after adjustment for age, sex, and body weight in proportional hazard analyses.Conclusions: Higher metabolic rates as reflected by 24EE or RMR predict early natural mortality, indicating that higher energy turnover may accelerate aging in humans. (J Clin Endocrinol Metab 96: E972-E976, 2011)