The role of NMDA receptor binding sites in ethanol place conditioning
The role of NMDA receptor binding sites in ethanol place conditioning
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DOI：
10.1037/0735-7044.118.4.822
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发表时间：
2004-08-01
影响因子：
1.9
通讯作者：
Cunningham, CL
中科院分区：
文献类型：
--
作者：
Boyce-Rustay, JM;Cunningham, CL
很少有人知道谷氨酸的具体作用，特别是它的行动在N-甲基-D-天冬氨酸（NMDA）受体，在乙醇奖励。通道阻断剂MK-801和氯胺酮、NMDA NR 2 B受体亚单位拮抗剂ifenprodil和CP-101，606以及甘氨酸（B）部分激动剂（+）-HA-966预处理不改变小鼠乙醇诱导的条件性位置偏爱（CPP）的获得。然而，预处理与竞争性拮抗剂CGP-37849衰减收购乙醇诱导的CPP。后续实验表明，CGP-37849也阻止了乙醇诱导和氯化锂诱导的条件性位置厌恶的获得，但本身并不产生奖励或厌恶效应。这些结果表明，NMDA受体谷氨酸结合位点是重要的乙醇位置条件。此外，这些结果表明CGP-37849通过损害学习这些任务的能力来调节乙醇位置条件反射。
Little is known about the specific role of glutamate, in particular its actions at N-methyl-D-aspartate (NMDA) receptors, in ethanol reward. Pretreatment with channel blockers MK-801 and ketamine, NMDA NR2B receptor subunit antagonists ifenprodil and CP-101,606, and the glycine(B) partial agonist (+)-HA-966 did not alter acquisition of ethanol-induced conditioned place preference (CPP) in mice. However, pretreatment with the competitive antagonist CGP-37849 attenuated acquisition of ethanol-induced CPP. Follow-up experiments indicated that CGP-37849 also blocked acquisition of ethanol-induced and lithium chloride-induced conditioned place aversion but did not produce rewarding or aversive effects on its own. These results suggest that the NMDA receptor glutamate binding site is important for ethanol place conditioning. Moreover, these results suggest CGP-37849 modulates ethanol place conditioning by impairing the ability to learn these tasks.