Comparison of implantation and pregnancy rates in African American and white women in an assisted reproductive technology practice
Comparison of implantation and pregnancy rates in African American and white women in an assisted reproductive technology practice
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DOI：
10.1016/s0015-0282(01)01853-2
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发表时间：
2001-07-01
影响因子：
6.7
通讯作者：
Boone, WR
中科院分区：
文献类型：
--
作者：
Nichols, JE;Higdon, HL;Boone, WR
目的：比较不孕的非裔美国人和白色妇女之间的TVF结果。设计：回顾性队列研究。设置：基于医院的IVF实践。患者：1996年11月至2000年6月期间接受IVF手术的妇女。干预：无。主要结局指标：植入率和妊娠率。结果：有24名非洲裔美国人和273名白色女性小于或等于40岁，分别接受了25个和333个IVF周期。与白色妇女相比，非裔美国妇女更有可能将输卵管因素作为主要诊断，生过孩子，并且以前接受过较少的辅助生殖技术（ART）周期。除了体重指数（BMI [kg/m2]，非裔美国人为27.1，白人为24.8）外，两组之间的临床变量无差异。非洲裔美国妇女的着床率高于白色妇女（分别为35%和23%）。非洲裔美国人的怀孕率为71%，白人为48%。在调整输卵管因素、BMT和产次后，非裔美国妇女与白色妇女的妊娠优势比从2.6增加到3.3。这是第一项研究证明，与接受ART的白色妇女相比，非洲裔美国妇女的临床妊娠率显著更高。这些数据与最近一项比较接受ART的两组妇女的研究强烈矛盾。敦促其他ART中心报告与种族有关的数据。(C)2001年，美国生殖医学会。
Objective: To compare TVF outcomes between infertile African American and white women.Design: Retrospective cohort study.Setting: Hospital-based IVF practice.Patient(s): Women undergoing IVF procedures between November 1996 and June 2000.Intervention(s): None.Main Outcomes Measure(s): Implantation and pregnancy rates.Result(s): There were 24 African American and 273 white women less than or equal to 40 years of age who underwent 25 and 333 IVF cycles, respectively. African American women were more likely to have had tubal factor as a primary diagnosis, to have had a child, and to have undergone fewer previous assisted reproductive technology (ART) cycles as compared to white women. No differences between the two groups for clinical variables were noted with the exception of body mass index (BMI [kg/m(2)], 27.1 in African Americans vs. 24.8 in whites). implantation rates were higher in African American than in white women (35% vs. 23%, respectively). Pregnancy rates were 71% in African Americans and 48% in whites. After adjustment for tubal factor, BMT, and parity, the odds ratio for pregnancy in African American women versus white women increased from 2.6 to 3.3.Conclusion(s): This is the first study to demonstrate a significantly higher clinical pregnancy rate in African American women as compared to white women undergoing ART. These data strongly contradict a recent study comparing the same two groups of women undergoing ART. We urge other ART centers to report their data pertaining to race. (C) 2001 by American Society for Reproductive Medicine.