The Generation R Study: design and cohort update until the age of 4 years
The Generation R Study: design and cohort update until the age of 4 years
复制标题
DOI：
10.1007/s10654-008-9309-4
复制
发表时间：
2008-12-01
影响因子：
13.6
通讯作者：
Hofman, Albert
中科院分区：
文献类型：
--
作者：
Jaddoe, Vincent W. V.;van Duijn, Cornelia M.;Hofman, Albert
R世代研究是一项以人群为基础的前瞻性队列研究，从胎儿期到成年早期。该研究旨在确定从胎儿生命到成年早期正常和异常生长，发育和健康的早期环境和遗传原因。该研究侧重于四个主要研究领域：（1）生长和身体发育;（2）行为和认知发展;（3）儿童疾病;（4）孕妇和儿童的健康和保健。共有9 778名分娩日期为2002年4月至2006年1月的母亲参加了这项研究。在所有出生时符合条件的儿童中，61%参加了这项研究。此外，还对1 232名孕妇及其子女进行了更详细的评估。在产前阶段和产后阶段直至4岁的数据收集包括问卷调查、详细的身体和超声波检查、行为观察和生物样本。本文提供了一个更新的研究设计和队列概况，直到儿童的年龄为4岁。最终，R世代研究的结果必须有助于制定优化孕妇和儿童健康和保健的战略。
The Generation R Study is a population-based prospective cohort study from fetal life until young adulthood. The study is designed to identify early environmental and genetic causes of normal and abnormal growth, development and health from fetal life until young adulthood. The study focuses on four primary areas of research: (1) growth and physical development; (2) behavioural and cognitive development; (3) diseases in childhood; and (4) health and healthcare for pregnant women and children. In total, 9,778 mothers with a delivery date from April 2002 until January 2006 were enrolled in the study. Of all eligible children at birth, 61% participate in the study. In addition, more detailed assessments are conducted in a subgroup of 1,232 pregnant women and their children. Data collection in the prenatal phase and postnatal phase until the age of 4 years includes questionnaires, detailed physical and ultrasound examinations, behavioural observations and biological samples. This paper gives an update of the study design and cohort profile until the children's age of 4 years. Eventually, results forthcoming from the Generation R Study have to contribute to the development of strategies for optimizing health and healthcare for pregnant women and children.