THE DROSOPHILA-TUMOROUS-LETHAL HEMATOPOIETIC ONCOGENE IS A DOMINANT MUTATION IN THE HOPSCOTCH LOCUS
THE DROSOPHILA-TUMOROUS-LETHAL HEMATOPOIETIC ONCOGENE IS A DOMINANT MUTATION IN THE HOPSCOTCH LOCUS
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DOI：
10.1007/bf00279527
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发表时间：
1993-04-01
期刊：
影响因子：
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通讯作者：
DEAROLF, CR
中科院分区：
文献类型：
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作者：
HANRATTY, WP;DEAROLF, CR
果蝇肿瘤致死 (Tum-1) 突变作为激活的癌基因，导致造血肿瘤、过度增殖和过早分化。 Tum-1 是跳房子 (hop) 基因座的显性突变，是细胞分裂和正确胚胎分割所必需的。黑色素瘤形成的 Tum-l 温度敏感期包括大部分幼虫和蛹的发育。
The Drosophila Tumorous-lethal (Tum-l) mutation acts as an activated oncogene, causing hematopoietic neoplasms, overproliferation, and premature differentiation. Tum-l is a dominant mutation in the hopscotch (hop) locus, which is required for cell division and for proper embryonic segmentation. The Tum-l temperature-sensitive period for melanotic tumor formation includes most of larval and pupal development.