Cardiovascular Magnetic Resonance Relaxometry Predicts Regional Functional Outcome After Experimental Myocardial Infarction
Cardiovascular Magnetic Resonance Relaxometry Predicts Regional Functional Outcome After Experimental Myocardial Infarction
复制标题
DOI：
10.1161/circimaging.116.006025
复制
发表时间：
2017-08-01
影响因子：
7.5
通讯作者：
Floegel, Ulrich
中科院分区：
文献类型：
--
作者：
Haberkorn, Sebastian M.;Jacoby, Christoph;Floegel, Ulrich
背景-钆基造影剂的心血管磁共振已被确立为心肌梗死（MI）后组织定征的金标准。除了准确的诊断，心血管磁共振预测MI后的结果的价值还有待证实。方法和结果-最近的心血管磁共振方法进行了系统比较，心肌梗死后使用永久性左前降支冠状动脉结扎（n=14）或50分钟缺血/再灌注（n=13）小鼠模型的组织损伤和功能障碍的量化。心血管磁共振包括心肌梗死后第1天和第21天的自然/造影后T1图、T2图和晚期钆增强。对于参数和功能测量的区域相关性，在200个扇区上分析左心室。对于T1标测，我们使用回顾性触发和可变翻转角分析。对自然T1图的扇形分析已经显示，在MI后急性期，两种MI模型之间的心肌组织纹理存在显著差异（自然T1第1天：永久结扎，1280.0 +/- 162.6 ms;缺血/再灌注，1115.0 +/- 140.5 ms; P
Background-Cardiovascular magnetic resonance with gadolinium-based contrast agents has established as gold standard for tissue characterization after myocardial infarction (MI). Beyond accurate diagnosis, the value of cardiovascular magnetic resonance to predict the outcome after MI has yet to be substantiated.Methods and Results-Recent cardiovascular magnetic resonance approaches were systematically compared for quantification of tissue injury and functional impairment after MI using murine models with permanent left anterior descending coronary artery ligation (n=14) or 50 minutes ischemia/reperfusion (n=13). Cardiovascular magnetic resonance included native/postcontrast T1 maps, T2 maps, and late gadolinium enhancement at days 1 and 21 post-MI. For regional correlation of parametric and functional measures, the left ventricle was analyzed over 200 sectors. For T1 mapping, we used retrospective triggering with variable flip angle analysis. Sectoral analysis of native T1 maps already revealed in the acute phase after MI substantial discrepancies in myocardial tissue texture between the 2 MI models (native T1 day 1: permanent ligation, 1280.0 +/- 162.6 ms; ischemia/reperfusion, 1115.0 +/- 140.5 ms; P